Correlation of Merkel cell polyomavirus positivity with PDGFR? mutations and survivin expression in Merkel cell carcinoma

B4 ZIGRINO MAUCHpublicationsBatinica M, Akgül B, Silling S, Mauch C, Zigrino P; J Dermatol Sci. 2015 Jul;79(1):43-9. doi: 10.1016/j.jdermsci.2015.04.002. Epub 2015 Apr 14.

Abstract BACKGROUND: Merkel cell carcinoma (MCC) is a neuroendocrine cancer of the skin postulated to originate through Merkel cell polyomavirus (MCPyV) oncogenesis and/or by...   Read More

Monocyte/macrophage MMP-14 modulates cell infiltration and T-cell attraction in contact dermatitis but not in murine wound healing

B4 ZIGRINO MAUCHpublications Klose A, Zigrino P, Mauch C; Am J Pathol. 2013 Mar;182(3):755-64. doi: 10.1016/j.ajpath.2012.11.028.

Abstract   Monocyte infiltration and subsequent differentiation into macrophages has been shown to be crucial during inflammation. Metalloproteinases are key enzymes in these processes,...   Read More

PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair

B2 WAGENER/ PAULSSONB4 ZIGRINO MAUCHpublications Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, Mauch C, Eckes B, Ulus H, Lund FE, Rappl G, Abken H, Paulsson M, Brachvogel B; PLoS One. 2013;8(1):e53262. doi: 10.1371/journal.pone.0053262. Epub 2013 Jan 4.

Abstract   Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may...   Read More

Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization

B4 ZIGRINO MAUCHpublicationsZigrino, P., Ayachi, O., Schild, A., Zamek, J., Kaltenberg, J., Nischt, R., Koch, M., and Mauch, C., Eur J Cell Biol. 2012 Oct;91(10):748-56. doi: 10.1016/j.ejcb.2012.05.003. Epub 2012 Jun 18.

Abstract Synthesis and activation of matrix metalloproteinases during wound healing are important for remodeling the extracellular matrix and modulating various cellular functions. The membrane-type...   Read More

Role of ADAM-15 in wound healing and melanoma development

B4 ZIGRINO MAUCHpublicationsSchönefuß, A., Abety, A.N., Zamek, J., Mauch, C. and Zigrino, P., Exp Dermatol. 2012 Jun;21(6):437-42. doi: 10.1111/j.1600-0625.2012.01490.x.

Abstract Proteins of the a disintegrin and metalloprotease (ADAM) family are transmembrane proteins involved in ectodomain shedding and in cellular interactions. In skin, ADAM-15...   Read More

Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration (2011)

B4 ZIGRINO MAUCHpublications Zhang Z, Chometon G, Wen T, Qu H, Mauch C, Krieg T, Aumailley M. Eur J Cell Biol. Jan;90(1):1-12, 2011.

Abstract Spatial and temporal expression of laminin isoforms is assumed to provide specific local information to neighboring cells. Here, we report the remarkably selective...   Read More

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development (2011)

B4 ZIGRINO MAUCHpublications Jin G, Zhang F, Chan KM, Xavier Wong HL, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z. EMBO J. 2011 Jun 1;30(11):2281-93.

Abstract Notch signalling controls the differentiation of haematopoietic progenitor cells (HPCs). Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a...   Read More

Accelerated wound repair in ADAM-9 knockout animals (2010)

B4 ZIGRINO MAUCHpublications Mauch C, Zamek J, Abety AN, Grimberg G, Fox JW, Zigrino P. J Invest Dermatol 130(8): 2120-2130

Abstract ADAM-9 belongs to a family of transmembrane, disintegrin-containing metalloproteinases (ADAMs) involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. Although the functions...   Read More

Stromal expression of MMP-13 is required for melanoma invasion and metastasis (2009)

B4 ZIGRINO MAUCHpublications Zigrino P, Kuhn I, Bäuerle T, Zamek J, Fox JW, Neumann S, Licht A, Schorpp-Kistner M, Angel P, Mauch C. J Invest Dermatol 129(11):2686-93

Abstract Tumor invasion and metastasis of malignant melanoma have been shown to require proteolytic degradation of the extracellular environment achieved primarily by enzymes of...   Read More

Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice (2009)

B4 ZIGRINO MAUCHpublications Koegel H, von Tobel L, Schäfer M, Alberti S, Kremmer E, Mauch C, Hohl D, Wang XJ, Beer HD, Bloch W, Nordheim A, Werner S. J Clin Invest. Apr;119(4):899-910, 2009.

Abstract The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin...   Read More

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