B7 EMING

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA Nat Commun 2016 Oct;7:13226 PMID: 27807348 Abstract Mammalian...   Read More

Tissue fibrosis: a pathomechanistically unresolved challenge and scary clinical problem

Eckes B, Eming SA Exp. Dermatol. 2016 Aug; PMID: 27513440 Abstract Fibrosis is defined as the replacement of healthy tissue by an excessive deposition...   Read More

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY,...   Read More

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

A5 BRÜNING/NIESSENB7 EMINGpublicationsKnuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA; J Immunol. 2015 Dec 1;195(11):5296-308. doi: 10.4049/jimmunol.1501237. Epub 2015 Oct 30.

Abstract Myeloid cells are key regulators of tissue homeostasis and disease. Alterations in cell-autonomous insulin/IGF-1 signaling in myeloid cells have recently been implicated in...   Read More

IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages

B7 EMINGpublicationsHos D, Bucher F, Regenfuss B, Dreisow ML, Bock F, Heindl LM, Eming SA, Cursiefen C; Am J Pathol. 2015 Nov 19. pii: S0002-9440(15)00574-X. doi: 10.1016/j.ajpath.2015.09.012. [Epub ahead of print]

Abstract The role of IL-10, a primarily anti-inflammatory cytokine, in the regulation of inflammatory lymphangiogenesis is undetermined. Herein, we show that IL-10 modulates corneal...   Read More

Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds

B7 EMINGpublicationsFreudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C; J Control Release. 2015 Oct 22;220(Pt A):79-88. doi: 10.1016/j.jconrel.2015.10.028. [Epub ahead of print]

Pubmed

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

B2 WAGENER/ PAULSSONB3 ECKES KRIEGB7 EMINGpublicationsKnipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA; Immunity. 2015 Oct 20;43(4):803-16. doi: 10.1016/j.immuni.2015.09.005.

Abstract Activation of the immune response during injury is a critical early event that determines whether the outcome of tissue restoration is regeneration or...   Read More

Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8

B7 EMINGpublicationsDing X, Lucas T, Marcuzzi GP, Pfister H, Eming SA; Cancer Res. 2015 Jan 15;75(2):330-43. doi: 10.1158/0008-5472.CAN-13-3007. Epub 2014 Nov 20.

Abstract Beta human papillomaviruses (HPV) have been suspected to be carcinogenic in nonmelanoma skin cancers (NMSC), but the basis for potential viral contributions to...   Read More

Wound repair and regeneration: mechanisms, signaling, and translation

B7 EMINGpublicationsEming SA, Martin P, Tomic-Canic M; Sci Transl Med. 2014 Dec 3;6(265):265sr6. doi: 10.1126/scitranslmed.3009337.

Abstract The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor...   Read More

Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing

B2 WAGENER/ PAULSSONB7 EMINGpublicationsLettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R; PLoS One. 2014 Aug 26;9(8):e105686. doi: 10.1371/journal.pone.0105686. eCollection 2014.

Abstract Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of...   Read More

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