publications

A role for Rac1 activity in malignant progression of sebaceous skin tumours

A3 NIEMANNpublicationsFrances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C; Oncogene. 2015 Oct;34(43):5505-12. doi: 10.1038/onc.2014.471. Epub 2015 Feb 9.

Abstract The small GTPase Rac1 is crucial for maintaining stem cells (SCs) in mammalian epidermis, and Rac1 activation leads to SC expansion. Loss or...   Read More

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

publications Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT; EMBO Mol Med. 2015 Feb 2;7(3):275-87. doi: 10.15252/emmm.201404916.

Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of...   Read More

Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

A3 NIEMANNpublicationsPetersson M, Reuter K, Brylka H, Kraus A, Schettina P, Niemann C; Nat Commun. 2015 Jan 22;6:5874. doi: 10.1038/ncomms6874.

Abstract Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate...   Read More

Necroptosis and its role in inflammation

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis...   Read More

Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8

B7 EMINGpublicationsDing X, Lucas T, Marcuzzi GP, Pfister H, Eming SA; Cancer Res. 2015 Jan 15;75(2):330-43. doi: 10.1158/0008-5472.CAN-13-3007. Epub 2014 Nov 20.

Abstract Beta human papillomaviruses (HPV) have been suspected to be carcinogenic in nonmelanoma skin cancers (NMSC), but the basis for potential viral contributions to...   Read More

Quality control mechanisms in cellular and systemic DNA damage responses

A7 SCHUMACHERpublications Ermolaeva MA, Dakhovnik A, Schumacher B; Ageing Res Rev. 2015 Sep;23(Pt A):3-11. doi: 10.1016/j.arr.2014.12.009. Epub 2015 Jan 3.

Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage...   Read More

Centrioles in the mouse: cilia and beyond

Bazzi H, Anderson KV Cell Cycle 2014;13(18):2809 PMID: 25486466 Abstract

Wound repair and regeneration: mechanisms, signaling, and translation

B7 EMINGpublicationsEming SA, Martin P, Tomic-Canic M; Sci Transl Med. 2014 Dec 3;6(265):265sr6. doi: 10.1126/scitranslmed.3009337.

Abstract The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor...   Read More

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

A4 PASPARAKISpublicationsKumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F; Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03422.

Abstract Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor...   Read More

The respiratory chain supercomplex organization is independent of COX7a2l isoforms

publicationsMourier A, Matic S, Ruzzenente B, Larsson NG, Milenkovic D; Cell Metab. 2014 Dec 2;20(6):1069-75. doi: 10.1016/j.cmet.2014.11.005.

Abstract The organization of individual respiratory chain complexes into supercomplexes or respirasomes has attracted great interest because of the implications for cellular energy conversion....   Read More

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