publications

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

A7 SCHUMACHERpublicationsMueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B; Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24.

Abstract Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage...   Read More

A C. elegans homolog of the Cockayne syndrome complementation group A gene

A7 SCHUMACHERpublicationsBabu V, Hofmann K, Schumacher B; DNA Repair (Amst). 2014 Dec;24:57-62. doi: 10.1016/j.dnarep.2014.09.011. Epub 2014 Nov 8.

Abstract Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA...   Read More

Genetic variation within transcriptional regulatory elements and its implications for human disease

Rada-Iglesias A Biol. Chem. 2014 Dec;395(12):1453-60 PMID: 25205712 Abstract Common human pathologies have a complicated etiology involving both genetic and environmental risk factors. Moreover,...   Read More

Proteome analysis in the assessment of ageing

A7 SCHUMACHERpublicationsNkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B; Ageing Res Rev. 2014 Nov;18:74-85. doi: 10.1016/j.arr.2014.09.002. Epub 2014 Sep 22.

Abstract Based on demographic trends, the societies in many developed countries are facing an increasing number and proportion of people over the age of...   Read More

Defective collagen VI α6 chain expression in the skeletal muscle of patients with collagen VI-related myopathies

B2 WAGENER/ PAULSSONpublicationsTagliavini F, Pellegrini C, Sardone F, Squarzoni S, Paulsson M, Wagener R, Gualandi F, Trabanelli C, Ferlini A, Merlini L, Santi S, Maraldi NM, Faldini C, Sabatelli P; Biochim Biophys Acta. 2014 Sep;1842(9):1604-12. doi: 10.1016/j.bbadis.2014.05.033. Epub 2014 Jun 5.

Abstract Collagen VI is a non-fibrillar collagen present in the extracellular matrix (ECM) as a complex polymer; the mainly expressed form is composed of...   Read More

Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding

B12 SENGLEpublicationsTroilo H, Zuk AV, Tunnicliffe RB, Wohl AP, Berry R, Collins RF, Jowitt TA, Sengle G, Baldock C; Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13063-8. doi: 10.1073/pnas.1404166111. Epub 2014 Aug 25.

Abstract Bone morphogenetic proteins (BMPs) orchestrate key cellular events, such as proliferation and differentiation, in development and homeostasis. Extracellular antagonists, such as chordin, are...   Read More

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P,...   Read More

Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

A10 IDENpublicationsSchlereth S, Refaian N, Iden S, Cursiefen C, Heindl; BioMed Research International. 2014:639058. Epub 2014 Sep 1

Abstract Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also...   Read More

Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing

B2 WAGENER/ PAULSSONB7 EMINGpublicationsLettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R; PLoS One. 2014 Aug 26;9(8):e105686. doi: 10.1371/journal.pone.0105686. eCollection 2014.

Abstract Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of...   Read More

Molecular and cellular basis of scleroderma

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T J. Mol. Med. 2014 Sep;92(9):913-24 PMID: 25030650 Abstract Systemic sclerosis (scleroderma) is a chronic...   Read More

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    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
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      Oktober 15 - Oktober 17

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