publications

Hexosamine pathway metabolites enhance protein quality control and prolong life

Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A Cell 2014 Mar;156(6):1167-78 PMID: 24630720 Abstract...   Read More

Impact of genomic damage and ageing on stem cell function

A7 SCHUMACHERpublicationsBehrens A, van Deursen JM, Rudolph KL, Schumacher B; Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928.

Abstract Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation...   Read More

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

publicationsDe Craene B, Denecker G, Vermassen P, Taminau J, Mauch C, Derore A, Jonkers J, Fuchs E, Berx G; Cell Death Differ. 2014 Feb;21(2):310-20. doi: 10.1038/cdd.2013.148. Epub 2013 Oct 25.

Abstract   Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during...   Read More

NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly

publicationsMetodiev MD, Spåhr H, Loguercio Polosa P, Meharg C, Becker C, Altmueller J, Habermann B, Larsson NG, Ruzzenente B; PLoS Genet. 2014 Feb 6;10(2):e1004110. doi: 10.1371/journal.pgen.1004110. eCollection 2014.

Abstract Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both the small (SSU) and large subunit (LSU). We demonstrate here that the...   Read More

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons

Neuhaus JF, Baris OR, Hess S, Moser N, Schröder H, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ Brain 2014 Feb;137(Pt 2):354-65 PMID: 24163249...   Read More

A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein

B2 WAGENER/ PAULSSONpublicationsBecker AK, Mikolajek H, Paulsson M, Wagener R, Werner JM; Structure. 2014 Feb 4;22(2):199-208. doi: 10.1016/j.str.2013.06.028. Epub 2013 Dec 12.

Abstract Von Willebrand factor A (VWA) domains are versatile protein interaction domains with N and C termini in close proximity placing spatial constraints on...   Read More

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane…

B3 ECKES KRIEGpublicationsRubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O; Matrix Biol. 2014 Feb;34:13-21. doi: 10.1016/j.matbio.2014.01.006. Epub 2014 Jan 27.

Abstract Maturation of the glomerular basement membrane (GBM) is essential for maintaining the integrity of the renal filtration barrier. Impaired maturation causes proteinuria and...   Read More

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy

A1 NIESSENpublicationsSallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H; Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

Abstract Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment...   Read More

Systemic DNA damage responses: organismal adaptations to genome instability

A7 SCHUMACHERpublicationsErmolaeva MA, Schumacher B; Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001. Epub 2014 Jan 15.

Abstract DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis...   Read More

Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants

A7 SCHUMACHERpublicationsWolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B; Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295. Epub 2014 Jan 14.

Abstract DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and a potential hindrance for cell cycle progression. Cells cope with UV-induced...   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

© 2017 SFB 829