publications

Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis

B2 WAGENER/ PAULSSONpublicationsSabatelli, P., Gualandi, F., Gara, S.K., Paulsson, M., Zamparelli, A., Martoni, E., Grumati, P., Pellegrini, C., Merlini, L., Ferlini, A. Maraldi, N.M., Bonaldo, P., Squarzoni, S. and Wagener, R., Matrix Biol. 2012 Apr;31(3):187-96. doi: 10.1016/j.matbio.2011.12.003. Epub 2011 Dec 30.

Abstract Collagen VI is a major extracellular matrix (ECM) protein with a critical role in maintaining skeletal muscle functional integrity. Mutations in COL6A1, COL6A2...   Read More

EMILIN- 3, a peculiar member of the EMILIN/Multimerin protein family, has a distinct expression pattern, forms oligomeric assemblies and serves as a pro TGF-

B2 WAGENER/ PAULSSONpublicationsSchiavinato, A., Becker, A.K., Zanetti, M., Corallo, D., Milanetto, M., Bizzotto, D., Bressan, G., Guljelmovic, M., Paulsson, M., Wagener, R., Braghetta, P. and Bonaldo, P., J Biol Chem. 2012 Mar 30;287(14):11498-515. doi: 10.1074/jbc.M111.303578. Epub 2012 Feb 10.

Abstract EMILIN-3 is a glycoprotein of the extracellular matrix belonging to a family that contains a characteristic N-terminal cysteine-rich EMI domain. Currently, EMILIN-3 is...   Read More

Inhibition of integrin α2β1 ameliorates glomerular injury

B3 ECKES KRIEGpublicationsBorza, C.M., Su, Y., Chen, X., Yu, L., Mont, S., Chetyrkin, S., Voziyan, P., Hudson, B.G., Billings, P.C., Jo, H., Bennett, J.S., DeGrado, W.F., Eckes, B., Zent, R., and Pozzi, A., J Am Soc Nephrol. 2012 Jun;23(6):1027-38. doi: 10.1681/ASN.2011040367. Epub 2012 Mar 22.

Abstract Mesangial cells and podocytes express integrins α1β1 and α2β1, which are the two major collagen receptors that regulate multiple cellular functions, including extracellular...   Read More

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation (2006)

publications+Stratis, A., Pasparakis, M., Rupec, R.A., Markur, D., Hartmann, K., Scharffetter-Kochanek, K., Peters, T., van Rooijen, N., Krieg, T., and Haase, I., J Clin Invest. 2006 Aug;116(8):2094-104.

Abstract Psoriasis is a common skin disease, the pathogenesis of which has not yet been resolved. In mice, epidermis-specific deletion of inhibitor of NF-kappaB...   Read More

Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin (2007)

publicationsRebholz, B., Haase, I., (corresponding author), Eckelt, B., Kuprash, D.V., Nedospasov, S.A., Flaig, M.J., Mailhammer, R., Weindl, G., Förster, I., Huss, R., Schmid, R.M., Pfeffer, K., and Rupec, R.A., Immunity. 2007 Aug;27(2):296-307. Epub 2007 Aug 9.

Abstract Inflammatory diseases at epithelial borders develop from aberrant interactions between resident cells of the tissue and invading immunocytes. Here, we unraveled basic functions...   Read More

Resolving lesions in human cutaneous leishmaniasis predominantly harbour chemokine receptor CXCR3-positive T helper 1/T cytotoxic type 1 cells (2010)

publicationsGeiger, B., Wenzel, J., Hantschke, M., Haase, I., Ständer, S., and von Stebut, E., Br J Dermatol. 2010 Apr;162(4):870-4. doi: 10.1111/j.1365-2133.2009.09573.x. Epub 2009 Nov 10.

Abstract BACKGROUND: Cutaneous leishmaniasis (CL) is an epidemic disease affecting millions of individuals worldwide. Treatment options have several side-effects and a vaccine does not...   Read More

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation (2011)

publicationsBonnet, M.C., Preukschat, D., Welz, P.S., van Loo, G., Ermolaeva, M.A., Bloch, W., Haase, I., and Pasparakis, M., Immunity. 2011 Oct 28;35(4):572-82. doi: 10.1016/j.immuni.2011.08.014. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity...   Read More

Combined role of collagen IX and COMP in cartilage matrix assembly – COMP counteracts collagen IX limitation of cartilage collagen fibril growth (2009)

publicationsBlumbach, K., Bastiaansen-Jenniskens, Y.M., DeGroot, J., Paulsson, M., Van Osch, G.V.J.M., and Zaucke, F., Arthritis Rheum. 2009 Dec;60(12):3676-85. doi: 10.1002/art.24979.

Abstract OBJECTIVE: Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to...   Read More

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

B2 WAGENER/ PAULSSONpublicationsAgarwal P, Schulz JN, Blumbach K, Andreasson K, Heinegård D, Paulsson M, Mauch C, Eming SA, Eckes B, Krieg T; Matrix Biol. 2013 Aug 8;32(6):325-31. doi: 10.1016/j.matbio.2013.02.010. Epub 2013 Mar 15.

Abstract Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered...   Read More

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165

A11 WICKSTRÖMpublicationsTraub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA; Biomaterials. 2013 Aug;34(24):5958-68. doi: 10.1016/j.biomaterials.2013.04.050. Epub 2013 May 14.

Abstract   Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood...   Read More

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