publications

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

A5 BRÜNING/NIESSENpublications Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM; Dev Cell. 2013 Jul 29;26(2):176-87. doi: 10.1016/j.devcel.2013.05.017

Abstract   The multilayered epidermis is established through a stratification program, which is accompanied by a shift from symmetric toward asymmetric divisions (ACD), a...   Read More

Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression.

A3 NIEMANNpublicationsKakanj P, Reuter K, Séquaris G, Wodtke C, Schettina P, Frances D, Zouboulis CC, Lanske B, Niemann C; Cell Rep. 2013 Jul 25;4(2):340-51. doi: 10.1016/j.celrep.2013.06.037. Epub 2013 Jul 18.

Abstract   Mutations in the hedgehog pathway drive the formation of tumors in many different organs, including the development of basal cell carcinoma in...   Read More

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT,...   Read More

ILK: a pseudokinase with a unique function in the integrin-actin linkage

Ghatak S, Morgner J, Wickström SA Biochem. Soc. Trans. 2013 Aug;41(4):995-1001 PMID: 23863169 Abstract ILK (integrin-linked kinase) is a central component of cell-matrix adhesions...   Read More

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

B3 ECKES KRIEGpublicationsDeppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B; J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

Abstract Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet organelles, ?-granules, release proteins...   Read More

Analysis of bulge stem cells from the epidermis using flow cytometry

A5 BRÜNING/NIESSENpublicationsVillani RM, Akyuz MD, Niessen MT, Niessen CM; Methods Mol Biol. 2013;989:33-43. doi: 10.1007/978-1-62703-330-5_4.

Abstract The epidermis is a multilayered epithelium consisting of multiple different progenitor cell populations, all of which are important to epidermal function. In order...   Read More

CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes

B13 FABRIpublicationsKlug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M; Immunology. 2013 May;139(1):121-8. doi: 10.1111/imm.12062.

Abstract The ability of T cells to activate antimicrobial pathways in infected macrophages is essential to host defence against many intracellular pathogens. Here, we...   Read More

mtDNA makes a U-turn for the mitochondrial nucleoid

publications Kukat C, Larsson NG; Trends Cell Biol. 2013 Sep;23(9):457-63. doi: 10.1016/j.tcb.2013.04.009. Epub 2013 May 27.

Abstract Mitochondria contain mtDNA derived from the ancestral endosymbiont genome. Important subunits of the oxidative phosphorylation system, which supplies cells with the energy currency...   Read More

Dysregulated autophagy contributes to podocyte damage in Fabry’s disease

publicationsLiebau MC, Braun F, Höpker K, Weitbrecht C, Bartels V, Müller RU, Brodesser S, Saleem MA, Benzing T, Schermer B, Cybulla M, Kurschat CE; PLoS One. 2013 May 17;8(5):e63506. doi: 10.1371/journal.pone.0063506. Print 2013.

Abstract Fabry’s disease results from an inborn error of glycosphingolipid metabolism that is due to deficiency of the lysosomal hydrolase α-galactosidase A. This X-linked...   Read More

Montagna Symposium 2012: Keeping it all together–adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function

A5 BRÜNING/NIESSENpublicationsGreen KJ, Niessen CM, Godsel LM, Kulesz-Martin MF, J Invest Dermatol. 2013 May;133(5):1124-8. doi: 10.1038/jid.2013.59.

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