Matrix metalloproteinase 14 is required for fibrous tissue expansion

September 21, 2015B4 ZIGRINO MAUCHTaylor SH, Yeung CY, Kalson NS, Lu Y, Zigrino P, Starborg T, Warwood S, Holmes DF, Canty-Laird EG, Mauch C, Kadler KE; Elife. 2015 Sep 21;4. pii: e09345. doi: 10.7554/eLife.09345.

Abstract Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is... Read More

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

September 11, 2015A10 IDENSchlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5965-73. doi: 10.1167/iovs.15-17290.

Abstract PURPOSE: Conjunctival melanoma (CM) is an ocular surface tumor that can lead to fatal metastases. Patients developing, tumor-associated lymphangiogenesis have a significantly increased... Read More

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

September 8, 2015A11 WICKSTRÖMMorgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA; Nat Commun. 2015 Sep 8;6:8198. doi: 10.1038/ncomms9198.

Abstract Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge... Read More

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

August 27, 2015publicationsKukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG; Proc Natl Acad Sci U S A. 2015 Aug 24. pii: 201512131. [Epub ahead of print]

Abstract Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the... Read More

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

August 26, 2015A10 IDENTuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K; Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

Abstract Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The... Read More

Epithelial Cell Death and Inflammation in Skin

August 15, 2015A4 PASPARAKIS

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized... Read More

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

August 13, 2015A7 SCHUMACHEREdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes.... Read More

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

August 11, 2015A10 IDENRefaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5691-7. doi: 10.1167/iovs.15-16829.

Abstract PURPOSE: Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior.... Read More

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

August 6, 2015publicationsLagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG; PLoS Genet. 2015 Aug 6;11(8):e1005423. doi: 10.1371/journal.pgen.1005423. eCollection 2015.

Abstract We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes... Read More

Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish

July 31, 2015B2 WAGENER/ PAULSSONGebauer JM, Kobbe B, Paulsson M, Wagener R; Matrix Biol. 2015 Jul 31. pii: S0945-053X(15)00124-9. doi: 10.1016/j.matbio.2015.07.001. [Epub ahead of print]

Abstract Collagen XXVIII is the last discovered member of the collagen superfamily and thus has been only sparsely investigated. We studied collagen XXVIII in... Read More

publications

Matrix metalloproteinase 14 is required for fibrous tissue expansion

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

Epithelial Cell Death and Inflammation in Skin

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish

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