publications

PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair

B2 WAGENER/ PAULSSONB4 ZIGRINO MAUCHpublications Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, Mauch C, Eckes B, Ulus H, Lund FE, Rappl G, Abken H, Paulsson M, Brachvogel B; PLoS One. 2013;8(1):e53262. doi: 10.1371/journal.pone.0053262. Epub 2013 Jan 4.

Abstract   Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may...   Read More

Development and homeostasis of the sebaceous gland

Niemann C, Horsley V Semin. Cell Dev. Biol. 2012 Oct;23(8):928-36 PMID: 22960253 Abstract The important role of epidermal appendages especially the sebaceous gland has...   Read More

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J Cell Stem Cell 2012 Nov;11(5):633-48 PMID: 22981823 Abstract Neural crest cells (NCC)...   Read More

Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization

B4 ZIGRINO MAUCHpublicationsZigrino, P., Ayachi, O., Schild, A., Zamek, J., Kaltenberg, J., Nischt, R., Koch, M., and Mauch, C., Eur J Cell Biol. 2012 Oct;91(10):748-56. doi: 10.1016/j.ejcb.2012.05.003. Epub 2012 Jun 18.

Abstract Synthesis and activation of matrix metalloproteinases during wound healing are important for remodeling the extracellular matrix and modulating various cellular functions. The membrane-type...   Read More

Experimental analysis of risk factors for ulcerative dermatitis in mice

A1 NIESSENA5 BRÜNING/NIESSENpublicationsNeuhaus, B., Niessen C.M., Mesaros A., Withers D.J., Krieg T. and Partridge L., Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

Abstract Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to...   Read More

Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures

B11 BAUMANN/ZAUCKEB2 WAGENER/ PAULSSONpublicationsBechtel, M., Keller, M., Bloch, W., Sasaki, T., Boukamp, P., Zaucke, F., Paulsson, M., and Nischt, R., FASEB J. 2012 Sep;26(9):3637-48. doi: 10.1096/fj.11-194597. Epub 2012 May 23.

Abstract Nidogen-1 and nidogen-2 are homologous proteins found in all basement membranes (BMs). They show comparable binding activities in vitro and partially redundant functions...   Read More

The in vivo function of mammalian cell and tissue polarity regulators: how to shape and maintain the epidermal barrier

A10 IDENpublications Niessen, M.T., Iden, S., Niessen, C.M., J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30

Abstract   The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration,...   Read More

Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition

Widmer C, Gebauer JM, Brunstein E, Rosenbaum S, Zaucke F, Drögemüller C, Leeb T, Baumann U Proc. Natl. Acad. Sci. U.S.A. 2012 Aug;109(33):13243-7 PMID:...   Read More

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signalling

publicationsChaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F., Cell. 2012 Aug 3;150(3):533-48. doi: 10.1016/j.cell.2012.06.028.

Abstract Nephronophthisis-related ciliopathies (NPHP-RC) are degenerative recessive diseases that affect kidney, retina, and brain. Genetic defects in NPHP gene products that localize to cilia...   Read More

A Mutation in the 5?-UTR of IFITM5 Creates an In-Frame Start Codon and Causes Autosomal-Dominant Osteogenesis Imperfecta Type V with Hyperplastic Callus

A10 IDENpublicationsSemler O, Garbes L, Keupp K, Swan D, Zimmermann K, Becker J, Iden S, Wirth B, Eysel P, Koerber F, Schoenau E, Bohlander SK, Wollnik B, Netzer C; The American Journal of Human Genetics 2012 Aug; 10;91(2):349-57. doi: 10.1016/j.ajhg.2012.06.011. Epub 2012 Aug 2.

Abstract Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disorder associated with bone fragility and susceptibility to fractures after minimal trauma. OI type...   Read More

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