publications

Role of ADAM-15 in wound healing and melanoma development

B4 ZIGRINO MAUCHpublicationsSchönefuß, A., Abety, A.N., Zamek, J., Mauch, C. and Zigrino, P., Exp Dermatol. 2012 Jun;21(6):437-42. doi: 10.1111/j.1600-0625.2012.01490.x.

Abstract Proteins of the a disintegrin and metalloprotease (ADAM) family are transmembrane proteins involved in ectodomain shedding and in cellular interactions. In skin, ADAM-15...   Read More

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

publicationsSeeger-Nukpezah, T., Liebau, M.C., Höpker, K., Lamkemeyer, T., Benzing, T., Golemis, E.A., Schermer, B., PLoS One. 2012;7(6):e38838. doi: 10.1371/journal.pone.0038838. Epub 2012 Jun 11.

Abstract Polo-like kinase (Plk1) plays a central role in regulating the cell cycle. Plk1-mediated phosphorylation is essential for centrosome maturation, and for numerous mitotic...   Read More

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA...   Read More

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis

A10 IDENpublications Iden S., van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG; Cancer Cell. 2012 Sep 11;22(3):389-403. doi: 10.1016/j.ccr.2012.08.004.

Abstract   Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes....   Read More

Classical and desmosomal cadherins at a glance

A1 NIESSENpublications Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP, J Cell Sci. 2012 Jun 1;125(Pt 11):2547-52. doi: 10.1242/jcs.066654.

Pubmed

Adherens junctions in Mammalian development, homeostasis and disease: lessons from mice

A1 NIESSENpublications Boggetti B, Niessen CM, Subcell Biochem. 2012;60:321-55. doi: 10.1007/978-94-007-4186-7_14.

Abstract Mice have proven to be a particularly powerful model to study molecular mechanisms of development and disease. The reason for this is the...   Read More

The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens

publicationsBehrens, D.T., Villone, D., Koch, M., Brunner, G., Sorokin, L., Robenek, H., Bruckner-Tuderman, L., Bruckner, P., and Hansen, U., J Biol Chem. 2012 May 25;287(22):18700-9. doi: 10.1074/jbc.M111.336073. Epub 2012 Apr 9.

Abstract The basement membrane between the epidermis and the dermis is indispensable for normal skin functions. It connects, and functionally separates, the epidermis and...   Read More

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure

B11 BAUMANN/ZAUCKEB2 WAGENER/ PAULSSONpublicationsAgarwal, P., Zwolanek, D., Keene, D. R., Schulz, J.N., Blumbach, K., Heinegard, D., Zaucke, F., Paulsson, M., Krieg, T., Koch, M., and Eckes, B., J Biol Chem. 2012 Jun 29;287(27):22549-59. doi: 10.1074/jbc.M111.335935. Epub 2012 May 9.

Abstract The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and...   Read More

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo

A1 NIESSENpublicationsNinomiya, H., David, R., Dam, E.W., Fagotto, F., Niessen, C.M. and Winklbauer, R., J Cell Sci. 2012 Apr 15;125(Pt 8):1877-83. doi: 10.1242/jcs.095315. Epub 2012 Feb 10.

Abstract Adhesion differences between cell populations are in principle a source of strong morphogenetic forces promoting cell sorting, boundary formation and tissue positioning, and...   Read More

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

A1 NIESSENA5 BRÜNING/NIESSENpublications Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC, Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which...   Read More

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