The in vivo function of mammalian cell and tissue polarity regulators–how to shape and maintain the epidermal barrier

A1 NIESSENpublications Niessen MT, Iden S, Niessen CM, J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30.

Abstract The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion...   Read More

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming...   Read More

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

A4 PASPARAKISA7 SCHUMACHERpublicationsLucas, T., Willenborg, S., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Nagy, A., Ferrara, N., Pasparakis, M., and Eming, S., Blood. 2012 Jul 19;120(3):613-25. doi: 10.1182/blood-2012-01-403386. Epub 2012 May 10.

Abstract Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are...   Read More

Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development

A9 HAMMERSCHMIDTpublicationsFeitosa, N. M., Zhang, J., Carney, T.J., Metzger, M., Korzh, V., Bloch, W. and Hammerschmidt, M., Dev Biol. 2012 Sep 15;369(2):235-48. doi: 10.1016/j.ydbio.2012.06.023. Epub 2012 Jul 6.

Abstract Hemicentin 1 (Hmcn1) and Hemicentin 2 (Hmcn2) belong to the fibulin family of extracellular matrix (ECM) proteins that play pivotal roles during development...   Read More

Role of ADAM-15 in wound healing and melanoma development

B4 ZIGRINO MAUCHpublicationsSchönefuß, A., Abety, A.N., Zamek, J., Mauch, C. and Zigrino, P., Exp Dermatol. 2012 Jun;21(6):437-42. doi: 10.1111/j.1600-0625.2012.01490.x.

Abstract Proteins of the a disintegrin and metalloprotease (ADAM) family are transmembrane proteins involved in ectodomain shedding and in cellular interactions. In skin, ADAM-15...   Read More

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

publicationsSeeger-Nukpezah, T., Liebau, M.C., Höpker, K., Lamkemeyer, T., Benzing, T., Golemis, E.A., Schermer, B., PLoS One. 2012;7(6):e38838. doi: 10.1371/journal.pone.0038838. Epub 2012 Jun 11.

Abstract Polo-like kinase (Plk1) plays a central role in regulating the cell cycle. Plk1-mediated phosphorylation is essential for centrosome maturation, and for numerous mitotic...   Read More

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA...   Read More

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis

A10 IDENpublications Iden S., van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG; Cancer Cell. 2012 Sep 11;22(3):389-403. doi: 10.1016/j.ccr.2012.08.004.

Abstract   Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes....   Read More

Classical and desmosomal cadherins at a glance

A1 NIESSENpublications Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP, J Cell Sci. 2012 Jun 1;125(Pt 11):2547-52. doi: 10.1242/jcs.066654.


Adherens junctions in Mammalian development, homeostasis and disease: lessons from mice

A1 NIESSENpublications Boggetti B, Niessen CM, Subcell Biochem. 2012;60:321-55. doi: 10.1007/978-94-007-4186-7_14.

Abstract Mice have proven to be a particularly powerful model to study molecular mechanisms of development and disease. The reason for this is the...   Read More

© 2017 SFB 829