publications

Cell polarity proteins and cancer

A10 IDENpublicationsEllenbroek, S.I.J., Iden, S., Collard, J.G., Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23.

Abstract   Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity...   Read More

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ EMBO J. 2012 Mar;31(5):1293-307 PMID: 22252130...   Read More

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

A10 IDENpublicationsIden, S., Misselwitz, S., Peddibhotla, S., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., Ebnet, K., J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27

Abstract   The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions...   Read More

The p53 network: cellular and systemic DNA damage responses in aging and cancer

A7 SCHUMACHERpublications Reinhardt HC, Schumacher B. Trends Genet. 2012 Mar;28(3):128-36.

Abstract Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that...   Read More

Stem cell dynamics in sebaceous gland morphogenesis in mouse skin

A3 NIEMANNpublicationsFrances, D., and Niemann. C., Dev Biol. 2012 Mar 1;363(1):138-46. doi: 10.1016/j.ydbio.2011.12.028. Epub 2011 Dec 27.

Abstract The hair follicle (HF) and the sebaceous gland (SG) constitute the two integral parts of the pilosebaceous unit and significantly contribute to the...   Read More

Role of NF-κB in epithelial biology

A4 PASPARAKISpublicationsPasparakis, M., Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.

Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the...   Read More

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

A5 BRÜNING/NIESSENB3 ECKES KRIEGpublicationsBlumbach, K., Niehoff, A., Belgardt, B.F., Ehlen, H.W., Schmitz, M., Hallinger, R., Schulz, J.N., Brüning, J.C., Krieg, T., Schubert, M., Gullberg, D., and Eckes, B., J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with...   Read More

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function

A1 NIESSENpublicationsFehrenschild, D., Galli, U., Breiden, B., Bloch, W., Schettina, P., Brodesser, S., Michels, C., Günschmann, C., Sandhoff, K., Niessen, C.M., and Niemann, C., J Invest Dermatol. 2012 Feb;132(2):337-45. doi: 10.1038/jid.2011.301. Epub 2011 Sep 22.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well...   Read More

A function for Rac1 in the terminal differentiation and pigmentation of hair

A3 NIEMANNA5 BRÜNING/NIESSENpublications Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen CM, Niemann C, Brakebusch C, Haase I; J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. doi: 10.1242/jcs.091868. Epub 2012 Jan 24.

Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to...   Read More

Microenvironmental regulation by fibrillin-1

B12 SENGLEpublicationsSengle, G., Tsutsui, K., Keene, D.R., Tufa, S.F., Carlson, E.J., Charbonneau, N.L., Ono, R.N., Sasaki, T., Wirtz, M.K., Samples, J.R., Fessler, L.I., Fessler, J.H., Sekiguchi, K.,Hayflick, S.J., and Sakai, L.Y., PLoS Genet. 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5.

Abstract   Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has...   Read More

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