publications

The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens

publicationsBehrens, D.T., Villone, D., Koch, M., Brunner, G., Sorokin, L., Robenek, H., Bruckner-Tuderman, L., Bruckner, P., and Hansen, U., J Biol Chem. 2012 May 25;287(22):18700-9. doi: 10.1074/jbc.M111.336073. Epub 2012 Apr 9.

Abstract The basement membrane between the epidermis and the dermis is indispensable for normal skin functions. It connects, and functionally separates, the epidermis and...   Read More

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure

B11 BAUMANN/ZAUCKEB2 WAGENER/ PAULSSONpublicationsAgarwal, P., Zwolanek, D., Keene, D. R., Schulz, J.N., Blumbach, K., Heinegard, D., Zaucke, F., Paulsson, M., Krieg, T., Koch, M., and Eckes, B., J Biol Chem. 2012 Jun 29;287(27):22549-59. doi: 10.1074/jbc.M111.335935. Epub 2012 May 9.

Abstract The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and...   Read More

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo

A1 NIESSENpublicationsNinomiya, H., David, R., Dam, E.W., Fagotto, F., Niessen, C.M. and Winklbauer, R., J Cell Sci. 2012 Apr 15;125(Pt 8):1877-83. doi: 10.1242/jcs.095315. Epub 2012 Feb 10.

Abstract Adhesion differences between cell populations are in principle a source of strong morphogenetic forces promoting cell sorting, boundary formation and tissue positioning, and...   Read More

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

A1 NIESSENA5 BRÜNING/NIESSENpublications Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC, Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which...   Read More

Cell polarity proteins and cancer

A10 IDENpublicationsEllenbroek, S.I.J., Iden, S., Collard, J.G., Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23.

Abstract   Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity...   Read More

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ EMBO J. 2012 Mar;31(5):1293-307 PMID: 22252130...   Read More

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

A10 IDENpublicationsIden, S., Misselwitz, S., Peddibhotla, S., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., Ebnet, K., J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27

Abstract   The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions...   Read More

The p53 network: cellular and systemic DNA damage responses in aging and cancer

A7 SCHUMACHERpublications Reinhardt HC, Schumacher B. Trends Genet. 2012 Mar;28(3):128-36.

Abstract Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that...   Read More

Stem cell dynamics in sebaceous gland morphogenesis in mouse skin

A3 NIEMANNpublicationsFrances, D., and Niemann. C., Dev Biol. 2012 Mar 1;363(1):138-46. doi: 10.1016/j.ydbio.2011.12.028. Epub 2011 Dec 27.

Abstract The hair follicle (HF) and the sebaceous gland (SG) constitute the two integral parts of the pilosebaceous unit and significantly contribute to the...   Read More

Role of NF-κB in epithelial biology

A4 PASPARAKISpublicationsPasparakis, M., Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.

Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the...   Read More

© 2017 SFB 829