Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice

B3 ECKES KRIEGPeters AS, Brunner G, Krieg T, Eckes B; Arch Dermatol Res. 2015 Mar;307(2):191-7. doi: 10.1007/s00403-014-1514-2. Epub 2014 Oct 28.

Abstract Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the...   Read More

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Stephan A, Fabri M Exp. Dermatol. 2015 Mar;24(3):161-6 PMID: 25421224 Abstract Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized...   Read More

Pathological implications of cadherin zonation in mouse liver

A1 NIESSENHempel M, Schmitz A, Winkler S, Kucukoglu O, Brückner S, Niessen C, Christ B; Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.

Abstract Both acute and chronic liver diseases are associated with ample re-modeling of the liver parenchyma leading to functional impairment, which is thus obviously...   Read More

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels

publications Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG; J Cell Biol. 2015 Feb 16;208(4):429-42. doi: 10.1083/jcb.201411100.

Abstract Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. Despite the established role of mitofusins (MFN1...   Read More

A role for Rac1 activity in malignant progression of sebaceous skin tumours

A3 NIEMANNFrances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C; Oncogene. 2015 Oct;34(43):5505-12. doi: 10.1038/onc.2014.471. Epub 2015 Feb 9.

Abstract The small GTPase Rac1 is crucial for maintaining stem cells (SCs) in mammalian epidermis, and Rac1 activation leads to SC expansion. Loss or...   Read More

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

publications Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT; EMBO Mol Med. 2015 Feb 2;7(3):275-87. doi: 10.15252/emmm.201404916.

Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of...   Read More

Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

A3 NIEMANNPetersson M, Reuter K, Brylka H, Kraus A, Schettina P, Niemann C; Nat Commun. 2015 Jan 22;6:5874. doi: 10.1038/ncomms6874.

Abstract Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate...   Read More

Necroptosis and its role in inflammation

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis...   Read More

Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8

B7 EMINGpublicationsDing X, Lucas T, Marcuzzi GP, Pfister H, Eming SA; Cancer Res. 2015 Jan 15;75(2):330-43. doi: 10.1158/0008-5472.CAN-13-3007. Epub 2014 Nov 20.

Abstract Beta human papillomaviruses (HPV) have been suspected to be carcinogenic in nonmelanoma skin cancers (NMSC), but the basis for potential viral contributions to...   Read More

Quality control mechanisms in cellular and systemic DNA damage responses

A7 SCHUMACHER Ermolaeva MA, Dakhovnik A, Schumacher B; Ageing Res Rev. 2015 Sep;23(Pt A):3-11. doi: 10.1016/j.arr.2014.12.009. Epub 2015 Jan 3.

Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage...   Read More

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