Abstract Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the... Read More
Stephan A, Fabri M Exp. Dermatol. 2015 Mar;24(3):161-6 PMID: 25421224 Abstract Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized... Read More
Abstract Both acute and chronic liver diseases are associated with ample re-modeling of the liver parenchyma leading to functional impairment, which is thus obviously... Read More
Abstract Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. Despite the established role of mitofusins (MFN1... Read More
Abstract The small GTPase Rac1 is crucial for maintaining stem cells (SCs) in mammalian epidermis, and Rac1 activation leads to SC expansion. Loss or... Read More
Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of... Read More
Abstract Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate... Read More
Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis... Read More
Abstract Beta human papillomaviruses (HPV) have been suspected to be carcinogenic in nonmelanoma skin cancers (NMSC), but the basis for potential viral contributions to... Read More
Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage... Read More
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