publications

Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation

Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS...   Read More

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

A10 IDENpublicationsEllenbroek, S.I.J., Iden, S., Collard, J.G., Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1

Abstract   Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer....   Read More

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

Rada-Iglesias A, Wysocka J Genome Med 2011 Jun;3(6):36 PMID: 21658297 Abstract Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent...   Read More

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

publications Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG. EMBO J. 2011 Nov 1.

Abstract Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and may, in principle, occur at many different levels. The leucine-rich pentatricopeptide...   Read More

Ciliopathies

publications Benzing T, Hildebrandt F, Katsanis N. (2011) New Engl J Med. 364 (16) :1533-43.

PubMed

Transition zone proteins and cilia dynamics

publications Benzing T, Schermer B. (2011) Nat Genetics, 43 (8) :723-4.

PubMed

The adapter protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

A4 PASPARAKISpublicationsBonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva M, Bloch W, Haase I, Pasparakis M (2011) Immunity ,2011 Oct 28;35(4):572-82. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity...   Read More

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

B13 FABRIpublicationsFabri, M., Stenger, S., Shin, D.M., Yuk, J.M., Liu, P.T., Realegeno, S., Lee, H.M., Krutzik, S.R., Schenk, M., Sieling, P.A., et al., Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

Abstract Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for...   Read More

Basement membrane diseases in zebrafish

A9 HAMMERSCHMIDTpublications Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M; Methods Cell Biol. 105, 191-222

Abstract Basement membranes (BMs) are a complex, sheet-like network of specialized extracellular matrix that underlies epithelial cells and surrounds muscle cells. They provide adherence...   Read More

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

B3 ECKES KRIEGpublications Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LAB, van den Berg WB, Kollias G, Eckes B, Pap T. , Arthritis Rheum 2011; accepted 16 September

Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in...   Read More

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