publications

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

A5 BRÜNING/NIESSENB3 ECKES KRIEGpublicationsBlumbach, K., Niehoff, A., Belgardt, B.F., Ehlen, H.W., Schmitz, M., Hallinger, R., Schulz, J.N., Brüning, J.C., Krieg, T., Schubert, M., Gullberg, D., and Eckes, B., J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with...   Read More

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function

A1 NIESSENpublicationsFehrenschild, D., Galli, U., Breiden, B., Bloch, W., Schettina, P., Brodesser, S., Michels, C., Günschmann, C., Sandhoff, K., Niessen, C.M., and Niemann, C., J Invest Dermatol. 2012 Feb;132(2):337-45. doi: 10.1038/jid.2011.301. Epub 2011 Sep 22.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well...   Read More

A function for Rac1 in the terminal differentiation and pigmentation of hair

A3 NIEMANNA5 BRÜNING/NIESSENpublications Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen CM, Niemann C, Brakebusch C, Haase I; J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. doi: 10.1242/jcs.091868. Epub 2012 Jan 24.

Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to...   Read More

Microenvironmental regulation by fibrillin-1

B12 SENGLEpublicationsSengle, G., Tsutsui, K., Keene, D.R., Tufa, S.F., Carlson, E.J., Charbonneau, N.L., Ono, R.N., Sasaki, T., Wirtz, M.K., Samples, J.R., Fessler, L.I., Fessler, J.H., Sekiguchi, K.,Hayflick, S.J., and Sakai, L.Y., PLoS Genet. 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5.

Abstract   Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has...   Read More

Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation

Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS...   Read More

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

A10 IDENpublicationsEllenbroek, S.I.J., Iden, S., Collard, J.G., Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1

Abstract   Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer....   Read More

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

Rada-Iglesias A, Wysocka J Genome Med 2011 Jun;3(6):36 PMID: 21658297 Abstract Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent...   Read More

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

publications Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG. EMBO J. 2011 Nov 1.

Abstract Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and may, in principle, occur at many different levels. The leucine-rich pentatricopeptide...   Read More

Ciliopathies

publications Benzing T, Hildebrandt F, Katsanis N. (2011) New Engl J Med. 364 (16) :1533-43.

PubMed

Transition zone proteins and cilia dynamics

publications Benzing T, Schermer B. (2011) Nat Genetics, 43 (8) :723-4.

PubMed

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