publications

Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions

A14 WIESNERA3 NIEMANNKloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R; J Invest Dermatol. 2015 Mar;135(3):679-89. doi: 10.1038/jid.2014.475. Epub 2014 Nov 5.

Abstract Here, we studied how epithelial energy metabolism impacts overall skin development by selectively deleting intraepithelial mtDNA in mice by ablating a key maintenance...   Read More

Genetic variation within transcriptional regulatory elements and its implications for human disease

Rada-Iglesias A Biol. Chem. 2014 Dec;395(12):1453-60 PMID: 25205712 Abstract Common human pathologies have a complicated etiology involving both genetic and environmental risk factors. Moreover,...   Read More

Proteome analysis in the assessment of ageing

A7 SCHUMACHERNkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B; Ageing Res Rev. 2014 Nov;18:74-85. doi: 10.1016/j.arr.2014.09.002. Epub 2014 Sep 22.

Abstract Based on demographic trends, the societies in many developed countries are facing an increasing number and proportion of people over the age of...   Read More

Defective collagen VI α6 chain expression in the skeletal muscle of patients with collagen VI-related myopathies

B2 WAGENER/ PAULSSONTagliavini F, Pellegrini C, Sardone F, Squarzoni S, Paulsson M, Wagener R, Gualandi F, Trabanelli C, Ferlini A, Merlini L, Santi S, Maraldi NM, Faldini C, Sabatelli P; Biochim Biophys Acta. 2014 Sep;1842(9):1604-12. doi: 10.1016/j.bbadis.2014.05.033. Epub 2014 Jun 5.

Abstract Collagen VI is a non-fibrillar collagen present in the extracellular matrix (ECM) as a complex polymer; the mainly expressed form is composed of...   Read More

Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding

B12 SENGLETroilo H, Zuk AV, Tunnicliffe RB, Wohl AP, Berry R, Collins RF, Jowitt TA, Sengle G, Baldock C; Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13063-8. doi: 10.1073/pnas.1404166111. Epub 2014 Aug 25.

Abstract Bone morphogenetic proteins (BMPs) orchestrate key cellular events, such as proliferation and differentiation, in development and homeostasis. Extracellular antagonists, such as chordin, are...   Read More

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P,...   Read More

Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

A10 IDENSchlereth S, Refaian N, Iden S, Cursiefen C, Heindl; BioMed Research International. 2014:639058. Epub 2014 Sep 1

Abstract Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also...   Read More

Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing

B2 WAGENER/ PAULSSONB7 EMINGLettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R; PLoS One. 2014 Aug 26;9(8):e105686. doi: 10.1371/journal.pone.0105686. eCollection 2014.

Abstract Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of...   Read More

Molecular and cellular basis of scleroderma

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T J. Mol. Med. 2014 Sep;92(9):913-24 PMID: 25030650 Abstract Systemic sclerosis (scleroderma) is a chronic...   Read More

Making proteins in the powerhouse

publicationsHällberg BM, Larsson NG; Cell Metab. 2014 Aug 5;20(2):226-40. doi: 10.1016/j.cmet.2014.07.001. Epub 2014 Jul 31.

Abstract Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest given that mitochondrial dysfunction is important in human pathology and aging. Similar...   Read More

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