The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T,...   Read More

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

A4 PASPARAKISpublications Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M., J Clin Invest. 2011, 121(7):2781-93

Abstract Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role...   Read More

Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells (2010)

B2 WAGENER/ PAULSSONpublications Grimal, S., Puech, S., Wagener, R., Ventéo, S., Carroll, P., Fichard-Carroll A. 2010. Glia. 58, 1977-87.

Abstract: Growing evidence indicates that collagens perform crucial functions during the development and organization of thenervous system. Collagen XXVIII is a recently discovered collagen...   Read More

Differential and restricted expression of novel collagen VI chains in mouse (2011)

B2 WAGENER/ PAULSSONpublications Gara, S.K., Grumati, P., Squarzoni, S., Sabatelli, P., Urciuolo, A., Bonaldo, P., Paulsson, M., Wagener, R., Matrix Biol. 30, 248-57

Abstract: Recently, three novel collagen VI chains, α4, α5 and α6, were identified. These are thought to substitute for the collagen VI α3 chain,...   Read More

Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate ?-carboxylation (2011)

B2 WAGENER/ PAULSSONpublications Neacsu, C.D., Grosch, M., Tejada, M., Winterpacht, A., Paulsson, M., Wagener, R., Tagariello, A. 2011. Matrix Biol. Aug 2011 [Epub ahead of print]

Abstract: UCMA (alternatively named GRP) is a novel member of the family of γ-carboxyglutamate (Gla) containing proteins that is mainly expressed in cartilage. We...   Read More

Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration (2011)

B4 ZIGRINO MAUCHpublications Zhang Z, Chometon G, Wen T, Qu H, Mauch C, Krieg T, Aumailley M. Eur J Cell Biol. Jan;90(1):1-12, 2011.

Abstract Spatial and temporal expression of laminin isoforms is assumed to provide specific local information to neighboring cells. Here, we report the remarkably selective...   Read More

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development (2011)

B4 ZIGRINO MAUCHpublications Jin G, Zhang F, Chan KM, Xavier Wong HL, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z. EMBO J. 2011 Jun 1;30(11):2281-93.

Abstract Notch signalling controls the differentiation of haematopoietic progenitor cells (HPCs). Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a...   Read More

A pivotal role for ? -1-antichymotrypsin in skin repair (2011)

B7 EMINGpublications Hoffmann DC, Textoris C, Oehme F, Klaassen T, Goppelt A, Römer A, Fugmann B, Davidson JM, Werner S. Krieg T, Eming SA. J Biol Chem

Abstract α1-antichymotrypsin (α1-ACT) is a specific inhibitor of leukocyte-derived chymotrypsin-like proteases with largely unknown functions in tissue repair. By examining human and murine skin...   Read More

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

publications Kukat C, Wurm CA, Spahr H, Falkenberg M, Larsson NG, and Jakobs S. Proc Natl Acad Sci U S A. 2011 Aug 01.

Abstract Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology...   Read More

Basement membranes in skin: unique matrix structures with diverse functions? (2009)

publications Breitkreutz D, Mirancea N, Nischt R. Histochem Cell Biol. 2009 Jul;132(1):1-10.

Abstract The view of extracellular matrix (ECM) has evolved from a merely scaffolding and space filling tissue element to an interface actively controlling cellular...   Read More

  • Upcoming Events

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