Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis

July 27, 2014B7 EMINGWillenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA; J Invest Dermatol. 2014 Jul;134(7):2005-15. doi: 10.1038/jid.2014.12. Epub 2014 Jan 9.

Abstract Conclusive evidence for the impact of mast cells (MCs) in skin repair is still lacking. Studies in mice examining the role of MC... Read More

Role of integrin signalling through integrin-linked kinase in skin physiology and pathology

July 21, 2014A11 WICKSTRÖM B3 ECKES KRIEG

Eckes B, Krieg T, Wickström SA Exp. Dermatol. 2014 Jul;23(7):453-6 PMID: 24773528 Abstract Cell-matrix adhesions provide structural stability to the tissue and regulate intracellular... Read More

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

July 4, 2014A4 PASPARAKIS

Kim C, Pasparakis M EMBO Mol Med 2014 Jul;6(7):970-83 PMID: 24952939 Abstract The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and... Read More

Understanding nucleotide excision repair and its roles in cancer and ageing

June 23, 2014B15 HOEIJMAKERS

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH Nat. Rev. Mol. Cell Biol. 2014 Jul;15(7):465-81 PMID: 24954209 Abstract Nucleotide excision repair (NER) eliminates various... Read More

Epidermal RelA Specifically Restricts Contact Allergen-Induced Inflammation and Apoptosis in Skin (2014)

June 17, 2014publicationsKumari S, Herzberg B, Pofahl R, Krieg T, Haase I; J Invest Dermatol. 2014 Apr 16. doi: 10.1038/jid.2014.193. [Epub ahead of print]

Abstract Strong inhibition of NF-κB signaling in the epidermis results in spontaneous skin inflammation in mice and men. As there is evidence for... Read More

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

June 2, 2014publications Agarwal P, Schulz JN, Blumbach K, Andreasson K, Heinegård D, Paulsson M, Mauch C, Eming SA, Eckes B, Krieg T; Matrix Biol. 2013 Aug 8;32(6):325-31. doi: 10.1016/j.matbio.2013.02.010. Epub 2013 Mar 15.

Abstract Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and... Read More

Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in humans and mice

June 2, 2014publications Zou Y, Zwolanek D, Izu Y, Gandhy S, Schreiber G, Brockmann K, Devoto M, Tian Z, Hu Y, Veit G, Meier M, Stetefeld J, Hicks D, Straub V, Voermans NC, Birk DE, Barton ER, Koch M, Bönnemann CG; Hum Mol Genet. 2014 May 1;23(9):2339-52. doi: 10.1093/hmg/ddt627. Epub 2013 Dec 11

Abstract Collagen VI-related myopathies are disorders of connective tissue presenting with an overlap phenotype combining clinical involvement from the muscle and from the... Read More

Overexpression of epigen during embryonic development induces reversible, EGFR-dependent sebaceous gland hyperplasia

June 2, 2014A3 NIEMANNDahlhoff M, Frances D, Kloepper JE, Paus R, Schäfer M, Niemann C, Schneider MR; Mol Cell Biol. 2014 Aug;34(16):3086-95. doi: 10.1128/MCB.00302-14. Epub 2014 Jun 2.

Abstract The epidermal growth factor receptor (EGFR) system is a key regulator of epithelial development and homeostasis. Its functions in the sebaceous gland (SG),... Read More

Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER

June 2, 2014publications Zwolanek D, Veit G, Eble JA, Gullberg D, Ruggiero F, Heino J, Meier M, Stetefeld J, Koch M; Biochem J. 2014 Apr 1;459(1):217-27. doi: 10.1042/BJ20130642.

Abstract Collagen XXII, a FACIT (fibril-associated collagen with interrupted triple helices), is expressed at the myotendinous junction and the articular surface of joint... Read More

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

June 2, 2014publications Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T; Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26.

Abstract Intermittent intense ultraviolet (UV) exposure represents an important aetiological factor in the development of malignant melanoma. The ability of UV radiation to... Read More

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