MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development (2011)

B4 ZIGRINO MAUCHpublications Jin G, Zhang F, Chan KM, Xavier Wong HL, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z. EMBO J. 2011 Jun 1;30(11):2281-93.

Abstract Notch signalling controls the differentiation of haematopoietic progenitor cells (HPCs). Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a...   Read More

A pivotal role for ? -1-antichymotrypsin in skin repair (2011)

B7 EMINGpublications Hoffmann DC, Textoris C, Oehme F, Klaassen T, Goppelt A, Römer A, Fugmann B, Davidson JM, Werner S. Krieg T, Eming SA. J Biol Chem

Abstract α1-antichymotrypsin (α1-ACT) is a specific inhibitor of leukocyte-derived chymotrypsin-like proteases with largely unknown functions in tissue repair. By examining human and murine skin...   Read More

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

publications Kukat C, Wurm CA, Spahr H, Falkenberg M, Larsson NG, and Jakobs S. Proc Natl Acad Sci U S A. 2011 Aug 01.

Abstract Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology...   Read More

Basement membranes in skin: unique matrix structures with diverse functions? (2009)

publications Breitkreutz D, Mirancea N, Nischt R. Histochem Cell Biol. 2009 Jul;132(1):1-10.

Abstract The view of extracellular matrix (ECM) has evolved from a merely scaffolding and space filling tissue element to an interface actively controlling cellular...   Read More

Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability (2010)

publications Vasudevan A, Ho MS, Weiergräber M, Nischt R, Schneider T, Lie A, Smyth N, Köhling R. Hippocampus. 2010 May;20(5):608-20.

Abstract The basement membrane (BM) is a specialized form of extracellular matrix (ECM) underlying epithelia and endothelia and surrounding many types of mesenchymal cells....   Read More

Transcription-blocking DNA damage in aging: a mechanism for hormesis (2009)

A7 SCHUMACHERpublications Schumacher B. Bioessays. 2009 Dec;31(12):1347-56.

Abstract Recent evidence from studies on DNA repair systems that are implicated in accelerated aging syndromes, have revealed a mechanism through which low levels...   Read More

Transcription-blocking DNA damage in aging and longevity (2009)

A7 SCHUMACHERpublications Garinis GA, Schumacher B. Cell Cycle. 2009 Jul 15;8(14):2134-5.


Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment (2009)

B2 WAGENER/ PAULSSONpublications Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R. Matrix Biol. 2009 Oct;28(8):456-62.

Abstract The VWA domain-containing extracellular matrix protein AMACO has not been extensively characterized and its function remains unknown. It has been proposed as a...   Read More

Enhanced contact allergen and UVB induced keratinocyte apoptosis in the absence of CD95/Fas/Apo-1 (2010)

publications Hedrych- Ozimina A, Hao Z, Pofahl R, Ussath D, Knaup R, Behrendt K, Krieg T, Haase I. Cell Death and Differentiation (2010) Aug 6.

Abstract FAS/CD95/Apo-1 is a ubiquitously expressed cell-surface receptor involved in the initiation of programmed cell death. Its function in epidermal keratinocytes has been incompletely...   Read More

Differential roles of macrophages in diverse phases of skin repair (2010)

B7 EMINGpublications Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, Müller W, Roers A, Eming SA. J Immunol 2010

Abstract Influx of macrophages plays a crucial role in tissue repair. However, the precise function of macrophages during the healing response has remained a...   Read More

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