Alternative proteolytic processing of hepatocyte growth factor during wound repair

A3 NIEMANNB7 EMINGpublications Buchstein N, Hoffmann N, Smola H, Lang S, Paulsson M, Niemann C, Krieg T, Eming SA. Am J Pathol 174(6):2116-28.

Abstract Wound healing is a crucial regenerative process in all organisms. We examined expression, integrity, and function of the proteins in the hepatocyte growth...   Read More

Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status (2010)

publications Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, Ehlen H, Vogel S, Zaucke F, von der Mark K, Bateman JF, Brachvogel B. J Bone Miner Res. 2010 Jun;25(6):1267-81.

Abstract Axial growth of long bones occurs through a coordinated process of growth plate chondrocyte proliferation and differentiation. This maturation of chondrocytes is reflected...   Read More

Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds

B7 EMINGpublications Eming SA, Koch M, Krieger A, Brachvogel B, Kreft S, Bruckner-Tuderman L, Krieg T, Shannon JD, Fox JW. J Proteome Res. 2010 Sep 3;9(9):4758-66.

Abstract Chronic wounds associated with vascular disease, diabetes mellitus, or aging are leading causes of morbidity in western countries and represent an unresolved clinical...   Read More

Accelerated wound repair in ADAM-9 knockout animals (2010)

B4 ZIGRINO MAUCHpublications Mauch C, Zamek J, Abety AN, Grimberg G, Fox JW, Zigrino P. J Invest Dermatol 130(8): 2120-2130

Abstract ADAM-9 belongs to a family of transmembrane, disintegrin-containing metalloproteinases (ADAMs) involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. Although the functions...   Read More

Stromal expression of MMP-13 is required for melanoma invasion and metastasis (2009)

B4 ZIGRINO MAUCHpublications Zigrino P, Kuhn I, Bäuerle T, Zamek J, Fox JW, Neumann S, Licht A, Schorpp-Kistner M, Angel P, Mauch C. J Invest Dermatol 129(11):2686-93

Abstract Tumor invasion and metastasis of malignant melanoma have been shown to require proteolytic degradation of the extracellular environment achieved primarily by enzymes of...   Read More

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis

B3 ECKES KRIEGpublications Veit G, Eckes B, Käpylä J, Zweers MC, Niland S, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M. J Biol Chem, August 5, 2011 The Journal of Biological Chemistry, 286, 27804-27813.

Abstract Cellular receptors for collagens belong to the family of β(1) integrins. In the epidermis, integrin α(2)β(1) is the only collagen-binding integrin present. Its...   Read More

The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5′ part of the split COL6A4 gene (2009)

B2 WAGENER/ PAULSSONpublications Wagener R, Gara SK, Kobbe B, Paulsson M, Zaucke F. (2009) Matrix Biol. 2009 Jul;28(6):307-10.

Abstract In a recent study the DVWA gene located on human chromosome 3p24.3 was identified as a susceptibility locus for knee osteoarthritis in Japanese...   Read More

Expression of the collagen VI ?5 and ?6 chains in normal human skin and in skin of patients with collagen VI-related myopathies (2010)

B2 WAGENER/ PAULSSONpublications Sabatelli P, Gara SK, Grumati P, Urciuolo A, Gualandi F, Curci R, Squarzoni S, Zamparelli A, Martoni E, Merlini L, Paulsson M, Bonaldo P, Wagener R (2010) J Invest Dermatol. 2011 Jan;131(1):99-107. Epub 2010 Sep 30.

Abstract Collagen VI is an extracellular matrix protein with critical roles in maintaining muscle and skin integrity and function. Skin abnormalities, including predisposition to...   Read More

Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma 1 chain (2011)

publications *Mokkapati S, *Fleger-Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, Smyth N, Nischt R. J Biol Chem 2011 Jan 21; 286(3):1911-8

Impaired wound healing in mice lacking the basement membrane protein nidogen 1 (2010)

publications Baranowsky A, *Mokkapati S, Bechtel M, Krügel J, Miosge N, Wickenhauser C, Smyth N, Nischt R. Matrix Biol 29, 15-21

Abstract Nidogens 1 and 2 are ubiquitous basement membrane (BM) components, whose interactions in particular with laminin, collagen IV and perlecan have been considered...   Read More

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