Cadherin mediated regulation of tight junctions in stratifying epithelia (2009)

A1 NIESSENpublications Michels, C., Yadranji, S. and Niessen C.M., N Y Acad Sci. 1165:163-8.

Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play...   Read More

Classical cadherins regulate desmosome formation (2009)

A1 NIESSENpublications Michels, C., Buchta T., Bloch W., Krieg, T, and Niessen C.M. J. Invest. Derm. 129:2072-5


FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

A4 PASPARAKISpublications Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M., Nature. 2011 Jul 31. doi: 10.1038/nature10273

Abstract Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). Epithelial barrier...   Read More

The Mitochondrial Electron Transport Chain is Dispensable for Proliferation and Differentiation of Epidermal Progenitor Cells

publications Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R, Wiesner RJ. Stem Cells. 2011 Jul 20.

Abstract Tissue stem cells, as well as germ line or embryonic stem cells, were shown to have reduced oxidative metabolism, which was proposed to...   Read More

MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome

publications Cámara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T, Erdjument-Bromage H, Tempst P, Hallberg BM, Gustafsson CM, Larsson NG. Cell Metab. 2011 May 4;13(5):527-39.

Abstract Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology...   Read More

Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability

B12 SENGLEpublicationsSengle, G., Ono, R.N., Sasaki, T., and Sakai, L.Y., J Biol Chem. 2011 Feb 18;286(7):5087-99. doi: 10.1074/jbc.M110.188615. Epub 2010 Dec 6.

Abstract The specific functions of the prodomains of TGFβ superfamily members are largely unknown. Interactions are known between prodomains of TGFβ-1-3 and latent TGFβ-binding...   Read More

Role of autophagy in the host response to microbial infection and potential for therapy

B13 FABRIpublicationsFabri, M., Realegeno, S.E., Jo, E.K., and Modlin, R.L., Curr Opin Immunol. 2011 Feb;23(1):65-70. doi: 10.1016/j.coi.2010.10.010. Epub 2010 Nov 9

Abstract   There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves...   Read More

A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J Nature 2011 Feb;470(7333):279-83 PMID: 21160473 Abstract Cell-fate transitions involve the integration of...   Read More

Genetic analyses of integrin signaling

A11 WICKSTRÖMpublicationsWickström, S., Radovanac, K., Fässler, R., Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a005116. doi: 10.1101/cshperspect.a005116

Abstract   The development of multicellular organisms, as well as maintenance of organ architecture and function, requires robust regulation of cell fates. This is...   Read More

A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis

B11 BAUMANN/ZAUCKEpublicationsHansen, U., Platz, N., Becker, A., Bruckner, P., Paulsson, M., and Zaucke ,F., Arthritis Rheum. 2011 Jan;63(1):159-67. doi: 10.1002/art.30073

Abstract OBJECTIVE: Mutations in human cartilage oligomeric matrix protein (COMP) cause multiple epiphyseal dysplasia or pseudoachondroplasia. Electron microscopic analyses of patient biopsy tissue have...   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

© 2017 SFB 829