Loss of LRPPRC causes ATP synthase deficiency

January 6, 2014publications Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG; Hum Mol Genet. 2014 May 15;23(10):2580-92. doi: 10.1093/hmg/ddt652. Epub 2014 Jan 6.

Abstract Defects of the oxidative phosphorylation system, in particular of cytochrome-c oxidase (COX, respiratory chain complex IV), are common causes of Leigh syndrome (LS),... Read More

Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice

January 2, 2014B2 WAGENER/ PAULSSON Bognar P, Nemeth I, Mayer B, Haluszka D, Wikonkal N, Ostorhazi E, John S, Paulsson M, Smyth N, Pasztoi M, Buzas EI, Szipocs R, Kolonics A, Temesvari E, Karpati S; J Invest Dermatol. 2014 Jan;134(1):105-11. doi: 10.1038/jid.2013.307. Epub 2013 Jul 24.

Abstract Recently, a transglutaminase 3 knockout (TGM3/KO) mouse was generated that showed impaired hair development, but no gross defects in the epidermal barrier,... Read More

Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution

January 1, 2014publicationsPatel TR, Bernards C, Meier M, McEleney K, Winzor DJ, Koch M, Stetefeld J; Matrix Biol. 2014 Jan;33:60-7. doi: 10.1016/j.matbio.2013.07.009. Epub 2013 Aug 12.

Abstract Nidogen-1 is a key basement membrane protein that is required for many biological activities. It is one of the central elements in organizing... Read More

The innate immune system as mediator of systemic DNA damage responses

November 13, 2013A7 SCHUMACHERErmolaeva M, Schumacher B; Commun Integr Biol. 2013 Nov 13;6(6):e26926. doi: 10.4161/cib.26926. eCollection 2013.

Abstract DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow... Read More

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

November 7, 2013A4 PASPARAKIS Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I; Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7.

Abstract Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays... Read More

The weakest link: a new paradigm for stabilizing the integrin-actin connection

September 27, 2013A11 WICKSTRÖM

Morgner J, Wickström SA Cell Cycle 2013 Sep;12(18):2929-30 PMID: 23974089 Abstract

Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis

September 16, 2013B11 BAUMANN/SENGLE

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent... Read More

Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice

September 11, 2013B3 ECKES KRIEGStange R, Kronenberg D, Timmen M, Everding J, Hidding H, Eckes B, Hansen U, Holtkamp M, Karst U, Pap T, Raschke MJ; Bone. 2013 Sep;56(1):48-54. doi: 10.1016/j.bone.2013.05.003. Epub 2013 May 13.

Abstract Collagen binding integrins are of essential importance in the crosstalk between cells and the extracellular matrix. Integrin α2β1 is a major receptor for... Read More

CD49b-dependent establishment of T helper cell memory

September 11, 2013B3 ECKES KRIEGHanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T; Immunol Cell Biol. 2013 Sep;91(8):524-31. doi: 10.1038/icb.2013.36. Epub 2013 Jul 30.

Abstract CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in... Read More

Systemic sclerosis with multiple nodules: characterization of the extracellular matrix

September 11, 2013B3 ECKES KRIEGMoinzadeh P, Agarwal P, Bloch W, Orteu C, Hunzelmann N, Eckes B, Krieg T; Arch Dermatol Res. 2013 Sep;305(7):645-52. doi: 10.1007/s00403-013-1383-0. Epub 2013 Jul 9.

Abstract Systemic sclerosis (SSc) is still an enigmatic disease of unknown etiology, although the pathophysiology is thought to be based on vascular alterations as... Read More

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