Abstract Defects of the oxidative phosphorylation system, in particular of cytochrome-c oxidase (COX, respiratory chain complex IV), are common causes of Leigh syndrome (LS),... Read More
Abstract Recently, a transglutaminase 3 knockout (TGM3/KO) mouse was generated that showed impaired hair development, but no gross defects in the epidermal barrier,... Read More
Abstract Nidogen-1 is a key basement membrane protein that is required for many biological activities. It is one of the central elements in organizing... Read More
Abstract DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow... Read More
Abstract Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays... Read More
Morgner J, Wickström SA Cell Cycle 2013 Sep;12(18):2929-30 PMID: 23974089 Abstract
Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent... Read More
Abstract Collagen binding integrins are of essential importance in the crosstalk between cells and the extracellular matrix. Integrin α2β1 is a major receptor for... Read More
Abstract CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in... Read More
Abstract Systemic sclerosis (SSc) is still an enigmatic disease of unknown etiology, although the pathophysiology is thought to be based on vascular alterations as... Read More
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