Role of autophagy in the host response to microbial infection and potential for therapy

B13 FABRIpublicationsFabri, M., Realegeno, S.E., Jo, E.K., and Modlin, R.L., Curr Opin Immunol. 2011 Feb;23(1):65-70. doi: 10.1016/j.coi.2010.10.010. Epub 2010 Nov 9

Abstract   There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves...   Read More

A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J Nature 2011 Feb;470(7333):279-83 PMID: 21160473 Abstract Cell-fate transitions involve the integration of...   Read More

Genetic analyses of integrin signaling

A11 WICKSTRÖMpublicationsWickström, S., Radovanac, K., Fässler, R., Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a005116. doi: 10.1101/cshperspect.a005116

Abstract   The development of multicellular organisms, as well as maintenance of organ architecture and function, requires robust regulation of cell fates. This is...   Read More

A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis

B11 BAUMANN/ZAUCKEpublicationsHansen, U., Platz, N., Becker, A., Bruckner, P., Paulsson, M., and Zaucke ,F., Arthritis Rheum. 2011 Jan;63(1):159-67. doi: 10.1002/art.30073

Abstract OBJECTIVE: Mutations in human cartilage oligomeric matrix protein (COMP) cause multiple epiphyseal dysplasia or pseudoachondroplasia. Electron microscopic analyses of patient biopsy tissue have...   Read More

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

B13 FABRIpublications Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., Keegan, C., Krutzik, S.R., Adams, J.S., Hewison, M., et al., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. doi: 10.1073/pnas.1011624108. Epub 2010 Dec 13.

Abstract We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes....   Read More

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

Denzel MS, Scimia MC, Zumstein PM, Walsh K, Ruiz-Lozano P, Ranscht B J. Clin. Invest. 2010 Dec;120(12):4342-52 PMID: 21041950 Abstract The circulating, adipocyte-secreted hormone...   Read More

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope

B7 EMINGpublications Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I, J Biol Chem. 2010 Nov 5;285(45):34932-8.

Abstract: Nesprins and emerin are structural nuclear envelope proteins that tether nuclei to the cytoskeleton. In this work, we identified the cytoskeleton-associated α-N/E-catenins as...   Read More

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

A11 WICKSTRÖMpublicationsWickström, S.A.*, Lange, A., Hess, M.J. Polleux, J., Spatz, J.P., Krüger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R., Dev Cell. 2010 Oct 19;19(4):574-88. doi: 10.1016/j.devcel.2010.09.007.

Abstract Caveolae are specialized compartments of the plasma membrane that are involved in signaling, endocytosis, and cholesterol transport. Their formation requires the transport of...   Read More

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

publicationsReinhardt, H.C., Hasskamp, P., Schmedding, I., Morandell, S., van Vugt, M., Wang, X., Linding, R., Ong, S.E., Weaver, D., Carr, S.A., Yaffe, M.B., Mol Cell. 2010 Oct 8;40(1):34-49. doi: 10.1016/j.molcel.2010.09.018.

Abstract Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire...   Read More

Fibrillin-1 and -2 differentially modulate endogenous TGF-? and BMP bioavailability during bone formation

B12 SENGLEpublicationsNistala, H., Lee-Arteaga, S., Smaldone, S., Siciliano, G., Carta, L., Ono, R., Sengle, G., Arteaga- Solis, E., Levasseur, R., Ducy, P., Sakai, L., Karsenty, and G., Ramirez, F., J Cell Biol. 2010 Sep 20;190(6):1107-21. doi: 10.1083/jcb.201003089.

Abstract Extracellular regulation of signaling by transforming growth factor (TGF)-β family members is emerging as a key aspect of organ formation and tissue remodeling....   Read More

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