T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

B13 FABRIpublications Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., Keegan, C., Krutzik, S.R., Adams, J.S., Hewison, M., et al., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. doi: 10.1073/pnas.1011624108. Epub 2010 Dec 13.

Abstract We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes....   Read More

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

Denzel MS, Scimia MC, Zumstein PM, Walsh K, Ruiz-Lozano P, Ranscht B J. Clin. Invest. 2010 Dec;120(12):4342-52 PMID: 21041950 Abstract The circulating, adipocyte-secreted hormone...   Read More

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope

B7 EMINGpublications Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I, J Biol Chem. 2010 Nov 5;285(45):34932-8.

Abstract: Nesprins and emerin are structural nuclear envelope proteins that tether nuclei to the cytoskeleton. In this work, we identified the cytoskeleton-associated α-N/E-catenins as...   Read More

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

A11 WICKSTRÖMpublicationsWickström, S.A.*, Lange, A., Hess, M.J. Polleux, J., Spatz, J.P., Krüger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R., Dev Cell. 2010 Oct 19;19(4):574-88. doi: 10.1016/j.devcel.2010.09.007.

Abstract Caveolae are specialized compartments of the plasma membrane that are involved in signaling, endocytosis, and cholesterol transport. Their formation requires the transport of...   Read More

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

publicationsReinhardt, H.C., Hasskamp, P., Schmedding, I., Morandell, S., van Vugt, M., Wang, X., Linding, R., Ong, S.E., Weaver, D., Carr, S.A., Yaffe, M.B., Mol Cell. 2010 Oct 8;40(1):34-49. doi: 10.1016/j.molcel.2010.09.018.

Abstract Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire...   Read More

Fibrillin-1 and -2 differentially modulate endogenous TGF-? and BMP bioavailability during bone formation

B12 SENGLEpublicationsNistala, H., Lee-Arteaga, S., Smaldone, S., Siciliano, G., Carta, L., Ono, R., Sengle, G., Arteaga- Solis, E., Levasseur, R., Ducy, P., Sakai, L., Karsenty, and G., Ramirez, F., J Cell Biol. 2010 Sep 20;190(6):1107-21. doi: 10.1083/jcb.201003089.

Abstract Extracellular regulation of signaling by transforming growth factor (TGF)-β family members is emerging as a key aspect of organ formation and tissue remodeling....   Read More

Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

B3 ECKES KRIEGpublications Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Muller GA, Gross O., Fibrogenesis & Tissue Repair 2010, 3:19.

Background Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate the integrity of the glomerular basement membrane (GBM) by sensing the...   Read More

In vivo studies of mutant fibrillin-1 microfibrils

B12 SENGLEpublicationsCharbonneau, N.L., Carlson, E.J., Tufa, S., Sengle, G., Carlberg, V.M., Ramirez, F., Keene, D.R., and Sakai, L.Y., J Biol Chem. 2010 Aug 6;285(32):24943-55. doi: 10.1074/jbc.M110.130021. Epub 2010 Jun 7.

Abstract In humans, mutations in fibrillin-1 result in a variety of genetic disorders with distinct clinical phenotypes. While most of the known mutations in...   Read More

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation

B3 ECKES KRIEGpublications Carracedo S, Lu N, Popova SN, Jonsson R, Eckes B, Gullberg D. J Biol Chem 285, 10434-10445, 2010  

Abstract Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding the factors that induce myofibroblast differentiation is paramount to preventing fibrotic healing....   Read More

Expression of integrin ß1 by fibroblasts is required for tissue repair in vivo

B3 ECKES KRIEGpublications Liu S, Shi-wen X, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. J Cell Sci 123, 3674-3682, 2010

Abstract In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue...   Read More

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