publications

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

A7 SCHUMACHERErmolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.

Abstract DNA damage responses have been well characterized with regard to their cell-autonomous checkpoint functions leading to cell cycle arrest, senescence and apoptosis. In...   Read More

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

A1 NIESSENNiessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM; J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.

PMID: 24019538 Abstract The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian...   Read More

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug

B12 SENGLE Tamminen JA, Parviainen V, Rönty M, Wohl AP, Murray L, Joenväärä S, Varjosalo M, Leppäranta O, Ritvos O, Sengle G, Renkonen R, Myllärniemi M, Koli K; Oncogenesis. 2013 Aug 26;2:e66. doi: 10.1038/oncsis.2013.29.

Abstract Malignant mesothelioma is a form of cancer that is highly resistant to conventional cancer therapy for which no major therapeutic advances have been...   Read More

T-cadherin is essential for adiponectin-mediated revascularization

Parker-Duffen JL, Nakamura K, Silver M, Kikuchi R, Tigges U, Yoshida S, Denzel MS, Ranscht B, Walsh K J. Biol. Chem. 2013 Aug;288(34):24886-97 PMID:...   Read More

Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice (2012)

publicationsMokkapati, S., Bechtel, M., Reibetanz, M., Miosge, N., and Nischt, R., J Histochem Cytochem. 2012 Apr;60(4):280-9. doi: 10.1369/0022155412436586. Epub 2012 Jan 19.

Abstract Nidogen 1 and 2 are ubiquitous basement membrane (BM) components. They show a divergent expression pattern in certain adult tissues with a prominent...   Read More

Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier (2012)

publicationsJohn, S., Thiebach, L., Frie, C., Mokkapati, S., Bechtel, M., Nischt, R., Rosser-Davies, S., Paulsson, M., and Smyth N., PLoS One. 2012;7(4):e34252. doi: 10.1371/journal.pone.0034252. Epub 2012 Apr 4.

Abstract Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization....   Read More

Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis

B2 WAGENER/ PAULSSONSabatelli, P., Gualandi, F., Gara, S.K., Paulsson, M., Zamparelli, A., Martoni, E., Grumati, P., Pellegrini, C., Merlini, L., Ferlini, A. Maraldi, N.M., Bonaldo, P., Squarzoni, S. and Wagener, R., Matrix Biol. 2012 Apr;31(3):187-96. doi: 10.1016/j.matbio.2011.12.003. Epub 2011 Dec 30.

Abstract Collagen VI is a major extracellular matrix (ECM) protein with a critical role in maintaining skeletal muscle functional integrity. Mutations in COL6A1, COL6A2...   Read More

EMILIN- 3, a peculiar member of the EMILIN/Multimerin protein family, has a distinct expression pattern, forms oligomeric assemblies and serves as a pro TGF-

B2 WAGENER/ PAULSSONSchiavinato, A., Becker, A.K., Zanetti, M., Corallo, D., Milanetto, M., Bizzotto, D., Bressan, G., Guljelmovic, M., Paulsson, M., Wagener, R., Braghetta, P. and Bonaldo, P., J Biol Chem. 2012 Mar 30;287(14):11498-515. doi: 10.1074/jbc.M111.303578. Epub 2012 Feb 10.

Abstract EMILIN-3 is a glycoprotein of the extracellular matrix belonging to a family that contains a characteristic N-terminal cysteine-rich EMI domain. Currently, EMILIN-3 is...   Read More

Inhibition of integrin α2β1 ameliorates glomerular injury

B3 ECKES KRIEGBorza, C.M., Su, Y., Chen, X., Yu, L., Mont, S., Chetyrkin, S., Voziyan, P., Hudson, B.G., Billings, P.C., Jo, H., Bennett, J.S., DeGrado, W.F., Eckes, B., Zent, R., and Pozzi, A., J Am Soc Nephrol. 2012 Jun;23(6):1027-38. doi: 10.1681/ASN.2011040367. Epub 2012 Mar 22.

Abstract Mesangial cells and podocytes express integrins α1β1 and α2β1, which are the two major collagen receptors that regulate multiple cellular functions, including extracellular...   Read More

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation (2006)

publications+Stratis, A., Pasparakis, M., Rupec, R.A., Markur, D., Hartmann, K., Scharffetter-Kochanek, K., Peters, T., van Rooijen, N., Krieg, T., and Haase, I., J Clin Invest. 2006 Aug;116(8):2094-104.

Abstract Psoriasis is a common skin disease, the pathogenesis of which has not yet been resolved. In mice, epidermis-specific deletion of inhibitor of NF-kappaB...   Read More

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