Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

B3 ECKES KRIEGpublications Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Muller GA, Gross O., Fibrogenesis & Tissue Repair 2010, 3:19.

Background Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate the integrity of the glomerular basement membrane (GBM) by sensing the...   Read More

In vivo studies of mutant fibrillin-1 microfibrils

B12 SENGLEpublicationsCharbonneau, N.L., Carlson, E.J., Tufa, S., Sengle, G., Carlberg, V.M., Ramirez, F., Keene, D.R., and Sakai, L.Y., J Biol Chem. 2010 Aug 6;285(32):24943-55. doi: 10.1074/jbc.M110.130021. Epub 2010 Jun 7.

Abstract In humans, mutations in fibrillin-1 result in a variety of genetic disorders with distinct clinical phenotypes. While most of the known mutations in...   Read More

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation

B3 ECKES KRIEGpublications Carracedo S, Lu N, Popova SN, Jonsson R, Eckes B, Gullberg D. J Biol Chem 285, 10434-10445, 2010  

Abstract Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding the factors that induce myofibroblast differentiation is paramount to preventing fibrotic healing....   Read More

Expression of integrin ß1 by fibroblasts is required for tissue repair in vivo

B3 ECKES KRIEGpublications Liu S, Shi-wen X, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. J Cell Sci 123, 3674-3682, 2010

Abstract In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue...   Read More

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts – role of TGFß1 levels and RhoA activity

B3 ECKES KRIEGpublications Blumbach K, Zweers MC, Brunner G, Peters AS, Schmitz M, Schulz JN, Schild A, Denton CP, Sakai T, Faessler R, Krieg T, Eckes B. J Cell Sci 123, 872-3883, 2010  

Abstract Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK)...   Read More

Genetic analysis of fin development in zebrafish identifies Furin and Hemicentin1 as potential novel Fraser Syndrome disease genes

A9 HAMMERSCHMIDTB2 WAGENER/ PAULSSONpublications Carney, T. J., Feitosa, N., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, R., Ingham, P.I. and Hammerschmidt, M. PLoS Genet. 6, e1000907

Abstract Using forward genetics, we have identified the genes mutated in two classes of zebrafish fin mutants. The mutants of the first class are...   Read More

Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner

A9 HAMMERSCHMIDTpublications Jänicke, M., Renisch, B. and Hammerschmidt, M. Int. J. Dev. Biol. 54, 837-850.

Abstract Grainyhead/CP2 transcription factor family members are widely conserved among the animal kingdom and have been implicated in different developmental processes. Thus far, nothing...   Read More

A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils

B11 BAUMANN/ZAUCKEpublications Otten, C., Hansen, U., Talke, A., Wagener, R., Paulsson, M., and Zaucke, F., Hum Mutat. 2010 Mar;31(3):254-63. doi: 10.1002/humu.21182

Abstract Mutations in matrilin-3 have been associated with common skeletal diseases like osteoarthritis as well as with the rare chondrodysplasias MED and SEMD. We...   Read More

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation

B12 SENGLEpublicationsTsutsui, K., Manabe, R.I., Yamada, T., Nakano, I., Oguri, Y., Keene, D.R., Sengle, G., Sakai, L.Y., and Sekiguchi, K., J Biol Chem. 2010 Feb 12;285(7):4870-82. doi: 10.1074/jbc.M109.076919. Epub 2009 Nov 23.

Abstract ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs)-like (ADAMTSL) proteins, a subgroup of the ADAMTS superfamily, share several domains with ADAMTS proteinases, including...   Read More

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

A11 WICKSTRÖMpublicationsWickström, S.A., Lange, A., Montanez, E., and Fässler, R., EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24.

Abstract   Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell...   Read More

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