Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin (2007)

publicationsRebholz, B., Haase, I., (corresponding author), Eckelt, B., Kuprash, D.V., Nedospasov, S.A., Flaig, M.J., Mailhammer, R., Weindl, G., Förster, I., Huss, R., Schmid, R.M., Pfeffer, K., and Rupec, R.A., Immunity. 2007 Aug;27(2):296-307. Epub 2007 Aug 9.

Abstract Inflammatory diseases at epithelial borders develop from aberrant interactions between resident cells of the tissue and invading immunocytes. Here, we unraveled basic functions...   Read More

Resolving lesions in human cutaneous leishmaniasis predominantly harbour chemokine receptor CXCR3-positive T helper 1/T cytotoxic type 1 cells (2010)

publicationsGeiger, B., Wenzel, J., Hantschke, M., Haase, I., Ständer, S., and von Stebut, E., Br J Dermatol. 2010 Apr;162(4):870-4. doi: 10.1111/j.1365-2133.2009.09573.x. Epub 2009 Nov 10.

Abstract BACKGROUND: Cutaneous leishmaniasis (CL) is an epidemic disease affecting millions of individuals worldwide. Treatment options have several side-effects and a vaccine does not...   Read More

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation (2011)

publicationsBonnet, M.C., Preukschat, D., Welz, P.S., van Loo, G., Ermolaeva, M.A., Bloch, W., Haase, I., and Pasparakis, M., Immunity. 2011 Oct 28;35(4):572-82. doi: 10.1016/j.immuni.2011.08.014. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity...   Read More

Combined role of collagen IX and COMP in cartilage matrix assembly – COMP counteracts collagen IX limitation of cartilage collagen fibril growth (2009)

publicationsBlumbach, K., Bastiaansen-Jenniskens, Y.M., DeGroot, J., Paulsson, M., Van Osch, G.V.J.M., and Zaucke, F., Arthritis Rheum. 2009 Dec;60(12):3676-85. doi: 10.1002/art.24979.

Abstract OBJECTIVE: Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to...   Read More

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

B2 WAGENER/ PAULSSONAgarwal P, Schulz JN, Blumbach K, Andreasson K, Heinegård D, Paulsson M, Mauch C, Eming SA, Eckes B, Krieg T; Matrix Biol. 2013 Aug 8;32(6):325-31. doi: 10.1016/j.matbio.2013.02.010. Epub 2013 Mar 15.

Abstract Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered...   Read More

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165

A11 WICKSTRÖMTraub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA; Biomaterials. 2013 Aug;34(24):5958-68. doi: 10.1016/j.biomaterials.2013.04.050. Epub 2013 May 14.

Abstract   Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood...   Read More

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

A5 BRÜNING/NIESSEN Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM; Dev Cell. 2013 Jul 29;26(2):176-87. doi: 10.1016/j.devcel.2013.05.017

Abstract   The multilayered epidermis is established through a stratification program, which is accompanied by a shift from symmetric toward asymmetric divisions (ACD), a...   Read More

Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression.

A3 NIEMANNKakanj P, Reuter K, Séquaris G, Wodtke C, Schettina P, Frances D, Zouboulis CC, Lanske B, Niemann C; Cell Rep. 2013 Jul 25;4(2):340-51. doi: 10.1016/j.celrep.2013.06.037. Epub 2013 Jul 18.

Abstract   Mutations in the hedgehog pathway drive the formation of tumors in many different organs, including the development of basal cell carcinoma in...   Read More

ILK: a pseudokinase with a unique function in the integrin-actin linkage

Ghatak S, Morgner J, Wickström SA Biochem. Soc. Trans. 2013 Aug;41(4):995-1001 PMID: 23863169 Abstract ILK (integrin-linked kinase) is a central component of cell-matrix adhesions...   Read More

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT,...   Read More

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