Abstract Inflammatory diseases at epithelial borders develop from aberrant interactions between resident cells of the tissue and invading immunocytes. Here, we unraveled basic functions... Read More
Abstract BACKGROUND: Cutaneous leishmaniasis (CL) is an epidemic disease affecting millions of individuals worldwide. Treatment options have several side-effects and a vaccine does not... Read More
Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity... Read More
Abstract OBJECTIVE: Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to... Read More
Abstract Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered... Read More
Abstract Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood... Read More
Abstract The multilayered epidermis is established through a stratification program, which is accompanied by a shift from symmetric toward asymmetric divisions (ACD), a... Read More
Abstract Mutations in the hedgehog pathway drive the formation of tumors in many different organs, including the development of basal cell carcinoma in... Read More
Ghatak S, Morgner J, Wickström SA Biochem. Soc. Trans. 2013 Aug;41(4):995-1001 PMID: 23863169 Abstract ILK (integrin-linked kinase) is a central component of cell-matrix adhesions... Read More
Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT,... Read More
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