CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

A11 WICKSTRÖMpublicationsWickström, S.A., Masoumi, K.C., Khochbin, S., Fässler, R., and Massoumi, R., EMBO J. 2010 Jan 6;29(1):131-44. doi: 10.1038/emboj.2009.317. Epub 2009 Nov 5.

Abstract CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating...   Read More

The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation

B11 BAUMANN/ZAUCKEpublicationsBieniossek, C., Niederhauser, B., and Baumann, U., Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21579-84. doi: 10.1073/pnas.0910708106. Epub 2009 Dec 2.

Abstract The hexameric membrane-spanning ATP-dependent metalloprotease FtsH is universally conserved in eubacteria, mitochondria, and chloroplasts, where it fulfills key functions in quality control and...   Read More

Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures

Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, van Osch GJ, Zaucke F Arthritis Rheum. 2009 Dec;60(12):3676-85 PMID: 19950300 Abstract OBJECTIVE: Defects in the...   Read More

Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation

Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM Differentiation 2009 Dec;78(5):292-300 PMID: 19683850 Abstract The hair fiber is...   Read More

Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

A11 WICKSTRÖMpublicationsMontanez, E., Wickström, S.A., Altstätter, J., Chu, H., and Fässler, R., EMBO J. 2009 Oct 21;28(20):3132-44. doi: 10.1038/emboj.2009.295. Epub 2009 Oct 1

Abstract During blood vessel development, vascular smooth muscle cells (vSMCs) and pericytes (PCs) are recruited to nascent vessels to stabilize them and to guide...   Read More

Integrin-linked kinase is an adaptor with essential functions during mouse development

A11 WICKSTRÖMpublicationsLange, A., Wickström S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R., Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.

Abstract The development of multicellular organisms requires integrin-mediated interactions between cells and their extracellular environment. Integrin binding to extracellular matrix catalyses assembly of multiprotein...   Read More

A vitamin for autophagy

B13 FABRIpublicationsFabri, M., and Modlin, R.L., Cell Host Microbe. 2009 Sep 17;6(3):201-3. doi: 10.1016/j.chom.2009.08.008.

Abstract Recent discoveries have revealed the importance of the vitamin D-dependent generation of antimicrobial peptides in human host defense against Mycobacterium tuberculosis. Now, Yuk...   Read More

Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice (2009)

B4 ZIGRINO MAUCHpublications Koegel H, von Tobel L, Schäfer M, Alberti S, Kremmer E, Mauch C, Hohl D, Wang XJ, Beer HD, Bloch W, Nordheim A, Werner S. J Clin Invest. Apr;119(4):899-910, 2009.

Abstract The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin...   Read More

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

B3 ECKES KRIEGpublications Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. Blood 114, 4897-906, 2009

Abstract Endorepellin, the C-terminal domain of perlecan, is a powerful angiogenesis inhibitor. To dissect the mechanism of endorepellin-mediated endothelial silencing, we used an antibody...   Read More

The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development

A9 HAMMERSCHMIDTpublications Slanchev K., Carney, T. J., Stemmler, M. P., Koschorz, M., Amsterdam, A., Schwarz, H. and Hammerschmidt, M. PLoS Genet. 5, e1000563

Abstract The aberrant expression of the transmembrane protein EpCAM is associated with tumor progression, affecting different cellular processes such as cell-cell adhesion, migration, proliferation,...   Read More

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