Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

A11 WICKSTRÖMpublicationsMontanez, E., Wickström, S.A., Altstätter, J., Chu, H., and Fässler, R., EMBO J. 2009 Oct 21;28(20):3132-44. doi: 10.1038/emboj.2009.295. Epub 2009 Oct 1

Abstract During blood vessel development, vascular smooth muscle cells (vSMCs) and pericytes (PCs) are recruited to nascent vessels to stabilize them and to guide...   Read More

Integrin-linked kinase is an adaptor with essential functions during mouse development

A11 WICKSTRÖMpublicationsLange, A., Wickström S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R., Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.

Abstract The development of multicellular organisms requires integrin-mediated interactions between cells and their extracellular environment. Integrin binding to extracellular matrix catalyses assembly of multiprotein...   Read More

A vitamin for autophagy

B13 FABRIpublicationsFabri, M., and Modlin, R.L., Cell Host Microbe. 2009 Sep 17;6(3):201-3. doi: 10.1016/j.chom.2009.08.008.

Abstract Recent discoveries have revealed the importance of the vitamin D-dependent generation of antimicrobial peptides in human host defense against Mycobacterium tuberculosis. Now, Yuk...   Read More

Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice (2009)

B4 ZIGRINO MAUCHpublications Koegel H, von Tobel L, Schäfer M, Alberti S, Kremmer E, Mauch C, Hohl D, Wang XJ, Beer HD, Bloch W, Nordheim A, Werner S. J Clin Invest. Apr;119(4):899-910, 2009.

Abstract The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin...   Read More

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

B3 ECKES KRIEGpublications Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. Blood 114, 4897-906, 2009

Abstract Endorepellin, the C-terminal domain of perlecan, is a powerful angiogenesis inhibitor. To dissect the mechanism of endorepellin-mediated endothelial silencing, we used an antibody...   Read More

The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development

A9 HAMMERSCHMIDTpublications Slanchev K., Carney, T. J., Stemmler, M. P., Koschorz, M., Amsterdam, A., Schwarz, H. and Hammerschmidt, M. PLoS Genet. 5, e1000563

Abstract The aberrant expression of the transmembrane protein EpCAM is associated with tumor progression, affecting different cellular processes such as cell-cell adhesion, migration, proliferation,...   Read More

A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta

B11 BAUMANN/ZAUCKEpublicationsDrögemüller, C., Becker, D., Brunner, A., Haase, B., Kircher, P., Seeliger, F., Fehr, M., Baumann, U., Lindblad-Toh, K., and Leeb, T., PLoS Genet. 2009 Jul;5(7):e1000579. doi: 10.1371/journal.pgen.1000579. Epub 2009 Jul 24.

Abstract Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth. Most human...   Read More

Interrelation of immunity and tissue repair or regeneration

A9 HAMMERSCHMIDTB7 EMINGpublications Eming SA, Hammerschmidt M, Krieg T, Roers A. Semin Cell Dev Biol. 2009 Jul;20(5):517-27.

Abstract Although tremendous progress has been achieved in understanding the molecular basis of tissue repair and regeneration in diverse model organisms, the tendency of...   Read More

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites

B12 SENGLEpublicationsOno, R.N., Sengle, G., Charbonneau, N.L., Carlberg, V., Bächinger, H.P., Sasaki, T., Lee-Arteaga, S., Zilberberg, L., Rifkin, D.B., Ramirez, F., Chu, M.L., and Sakai, L.Y., J Biol Chem. 2009 Jun 19;284(25):16872-81. doi: 10.1074/jbc.M809348200. Epub 2009 Apr 6.

Abstract Latent transforming growth factor (TGF) beta-binding proteins (LTBPs) interact with fibrillin-1. This interaction is important for proper sequestration and extracellular control of TGFbeta....   Read More

Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer

Denzel MS, Hebbard LW, Shostak G, Shapiro L, Cardiff RD, Ranscht B Clin. Cancer Res. 2009 May;15(10):3256-64 PMID: 19447866 Abstract PURPOSE: High levels of...   Read More

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