A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta

B11 BAUMANN/ZAUCKEpublicationsDrögemüller, C., Becker, D., Brunner, A., Haase, B., Kircher, P., Seeliger, F., Fehr, M., Baumann, U., Lindblad-Toh, K., and Leeb, T., PLoS Genet. 2009 Jul;5(7):e1000579. doi: 10.1371/journal.pgen.1000579. Epub 2009 Jul 24.

Abstract Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth. Most human...   Read More

Interrelation of immunity and tissue repair or regeneration

A9 HAMMERSCHMIDTB7 EMINGpublications Eming SA, Hammerschmidt M, Krieg T, Roers A. Semin Cell Dev Biol. 2009 Jul;20(5):517-27.

Abstract Although tremendous progress has been achieved in understanding the molecular basis of tissue repair and regeneration in diverse model organisms, the tendency of...   Read More

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites

B12 SENGLEpublicationsOno, R.N., Sengle, G., Charbonneau, N.L., Carlberg, V., Bächinger, H.P., Sasaki, T., Lee-Arteaga, S., Zilberberg, L., Rifkin, D.B., Ramirez, F., Chu, M.L., and Sakai, L.Y., J Biol Chem. 2009 Jun 19;284(25):16872-81. doi: 10.1074/jbc.M809348200. Epub 2009 Apr 6.

Abstract Latent transforming growth factor (TGF) beta-binding proteins (LTBPs) interact with fibrillin-1. This interaction is important for proper sequestration and extracellular control of TGFbeta....   Read More

Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer

Denzel MS, Hebbard LW, Shostak G, Shapiro L, Cardiff RD, Ranscht B Clin. Cancer Res. 2009 May;15(10):3256-64 PMID: 19447866 Abstract PURPOSE: High levels of...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERSpublications Garinis, G.A., Uittenboogaard L.M., Stachelscheid H., van Ijcken, W. , Breit T.M., van Steeg H., Mullenders L.H.F., van der Horst G.T.J., Brüning J.C., Niessen C.M., Hoeijmakers J.H.J, and Schumacher B. Nat. Cell Biol.. 11:604-15.

Abstract The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Clonal expansion of different mtDNA variants without selective advantage in solid tumors

Gekeler J, Zsurka G, Kunz WS, Preuss SF, Klussmann JP, Guntinas-Lichius O, Wiesner RJ Mutat. Res. 2009 Mar;662(1-2):28-32 PMID: 19114048 Abstract In search of...   Read More

Genetic and cell biological analysis of integrin outside-in signaling

A11 WICKSTRÖMpublicationsLegate, K.R., Wickström, S.A., Fässler, R., Genes Dev. 2009 Feb 15;23(4):397-418. doi: 10.1101/gad.1758709.

Abstract Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their...   Read More

Crosstalk between small GTPases and polarity proteins in cell polarization

A10 IDENpublicationsIden, S., Collard, J.G. (2008), Nat. Rev. Mol. Cell Biol.11, 846-59.

Abstract Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity...   Read More

A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7

B12 SENGLEpublicationsSengle, G., Ono, R., Lyons, K.M., Bächinger, H.P., and Sakai, L.Y., J Mol Biol. 2008 Sep 12;381(4):1025-39. doi: 10.1016/j.jmb.2008.06.074. Epub 2008 Jul 2.

Abstract Bone morphogenetic proteins (BMPs) are morphogens with long-range signaling activities. BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently...   Read More

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

B12 SENGLEpublications Sengle, G., Charbonneau, N.L., Ono, R.N., Sasaki, T., Alvarez, J., Keene, D.R., Bächinger H.P., and Sakai, L.Y., J Biol Chem. 2008 May 16;283(20):13874-88. doi: 10.1074/jbc.M707820200. Epub 2008 Mar 13.

Abstract Both latent transforming growth factor-beta (TGF-beta)-binding proteins fibrillins are components of microfibril networks, and both interact with members of the TGF-beta family of...   Read More

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