publications

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERSpublications Garinis, G.A., Uittenboogaard L.M., Stachelscheid H., van Ijcken, W. , Breit T.M., van Steeg H., Mullenders L.H.F., van der Horst G.T.J., Brüning J.C., Niessen C.M., Hoeijmakers J.H.J, and Schumacher B. Nat. Cell Biol.. 11:604-15.

Abstract The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Clonal expansion of different mtDNA variants without selective advantage in solid tumors

Gekeler J, Zsurka G, Kunz WS, Preuss SF, Klussmann JP, Guntinas-Lichius O, Wiesner RJ Mutat. Res. 2009 Mar;662(1-2):28-32 PMID: 19114048 Abstract In search of...   Read More

Genetic and cell biological analysis of integrin outside-in signaling

A11 WICKSTRÖMpublicationsLegate, K.R., Wickström, S.A., Fässler, R., Genes Dev. 2009 Feb 15;23(4):397-418. doi: 10.1101/gad.1758709.

Abstract Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their...   Read More

Crosstalk between small GTPases and polarity proteins in cell polarization

A10 IDENpublicationsIden, S., Collard, J.G. (2008), Nat. Rev. Mol. Cell Biol.11, 846-59.

Abstract Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity...   Read More

A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7

B12 SENGLEpublicationsSengle, G., Ono, R., Lyons, K.M., Bächinger, H.P., and Sakai, L.Y., J Mol Biol. 2008 Sep 12;381(4):1025-39. doi: 10.1016/j.jmb.2008.06.074. Epub 2008 Jul 2.

Abstract Bone morphogenetic proteins (BMPs) are morphogens with long-range signaling activities. BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently...   Read More

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

B12 SENGLEpublications Sengle, G., Charbonneau, N.L., Ono, R.N., Sasaki, T., Alvarez, J., Keene, D.R., Bächinger H.P., and Sakai, L.Y., J Biol Chem. 2008 May 16;283(20):13874-88. doi: 10.1074/jbc.M707820200. Epub 2008 Mar 13.

Abstract Both latent transforming growth factor-beta (TGF-beta)-binding proteins fibrillins are components of microfibril networks, and both interact with members of the TGF-beta family of...   Read More

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

B13 FABRIpublicationsSieling, P.A., Hill, P.J., Dobos, K.M., Brookman, K., Kuhlman, A.M., Fabri, M., Krutzik, S.R., Rea, T.H., Heaslip, D.G., Belisle, J.T., et al., J Immunol. 2008 May 1;180(9):5833-42.

Abstract CD4(+) T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an Ag...   Read More

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

A11 WICKSTRÖMpublicationsWang, H.V., Chang, L.W., Brixius, K., Wickström, S.A, Montanez, E., Thievessen, I., Schwander, M., Müller, U., Bloch, W., Mayer, U., Fässler, R., J Cell Biol. 2008 Mar 10;180(5):1037-49. doi: 10.1083/jcb.200707175

Abstract Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1...   Read More

Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry

Bazzi H, Christiano AM Curr. Opin. Cell Biol. 2007 Oct;19(5):515-20 PMID: 17951043 Abstract Desmosomal cadherins constitute the adhesive core of desmosomes. Different desmosomal cadherins...   Read More

Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M Development 2007 Oct;134(19):3461-71 PMID: 17728346 Abstract Epithelial integrity...   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

© 2017 SFB 829