Microenvironmental regulation by fibrillin-1

January 13, 2012B12 SENGLESengle, G., Tsutsui, K., Keene, D.R., Tufa, S.F., Carlson, E.J., Charbonneau, N.L., Ono, R.N., Sasaki, T., Wirtz, M.K., Samples, J.R., Fessler, L.I., Fessler, J.H., Sekiguchi, K.,Hayflick, S.J., and Sakai, L.Y., PLoS Genet. 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5.

Abstract Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has... Read More

Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation

January 6, 2012B14 DENZEL

Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS... Read More

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

January 1, 2012A10 IDENEllenbroek, S.I.J., Iden, S., Collard, J.G., Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1

Abstract Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer.... Read More

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

November 15, 2011A13 RADA-IGLESIAS

Rada-Iglesias A, Wysocka J Genome Med 2011 Jun;3(6):36 PMID: 21658297 Abstract Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent... Read More

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

November 3, 2011publications Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG. EMBO J. 2011 Nov 1.

Abstract Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and may, in principle, occur at many different levels. The leucine-rich pentatricopeptide... Read More

Ciliopathies

October 31, 2011publications Benzing T, Hildebrandt F, Katsanis N. (2011) New Engl J Med. 364 (16) :1533-43.

PubMed

Transition zone proteins and cilia dynamics

October 31, 2011publications Benzing T, Schermer B. (2011) Nat Genetics, 43 (8) :723-4.

PubMed

The adapter protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

October 28, 2011A4 PASPARAKISBonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva M, Bloch W, Haase I, Pasparakis M (2011) Immunity ,2011 Oct 28;35(4):572-82. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity... Read More

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

October 12, 2011B13 FABRIFabri, M., Stenger, S., Shin, D.M., Yuk, J.M., Liu, P.T., Realegeno, S., Lee, H.M., Krutzik, S.R., Schenk, M., Sieling, P.A., et al., Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

Abstract Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for... Read More

Basement membrane diseases in zebrafish

October 5, 2011A9 HAMMERSCHMIDT Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M; Methods Cell Biol. 105, 191-222

Abstract Basement membranes (BMs) are a complex, sheet-like network of specialized extracellular matrix that underlies epithelial cells and surrounds muscle cells. They provide adherence... Read More

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