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The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

B3 ECKES KRIEG Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LAB, van den Berg WB, Kollias G, Eckes B, Pap T. , Arthritis Rheum 2011; accepted 16 September

Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in...   Read More

TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

A3 NIEMANN Petersson M, Brylka H, Kraus A, John S, Rappl G, Schettina P, and Niemann C. (2011) EMBO J. 30: 3004-3018.

Abstract Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor...   Read More

CF/Lef1 mediated control of lipid metabolism regulates skin barrier function

A3 NIEMANN Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser, S, Michels C, Günschmann, C, Sandhoff K, Niessen C, and Niemann C. J Invest Dermatol. Sept 2011.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well...   Read More

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons

publications Chiang, LY., J. Hu, K. Poole, B.E. Oliveira, N. Duarte, A.B. Sierra, L. Bruckner-Tuderman, M. Koch, and G.R. Lewin. 2011. Nat. Neurosci 14, 993–1000

Abstract: Laminin-332 is a major component of the dermo-epidermal skin basement membrane and maintains skin integrity. The transduction of mechanical force into electrical signals...   Read More

Extracellular matrix in angiogenesis: dynamic structures with translational potential (2011)

B7 EMING Eming SA, Hubbell JA, Exp Dermatol 20(7):605-1.

Abstract: The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function,...   Read More

Sealing the gap between nuclear DNA damage and longevity (2009)

A7 SCHUMACHERB15 HOEIJMAKERS Schumacher B, Hoeijmakers JH, Garinis GA, Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7. Epub 2008 Nov 5.

Abstract: A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009)

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERS Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B, Nature Cell Biol. 2009 May;11(5):604-15.

Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development (2010)

A7 SCHUMACHERB15 HOEIJMAKERS Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W., PLoS Genet. 2010 May 6;6:e1000941.

Abstract: Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled...   Read More

Next Generation Sequencing of miRNAs – Strategies, Resources and Methods (2010)

A7 SCHUMACHER Motameny S, Wolters S, Nürnberg P, Schumacher B., Genes. 2010; 1(1):70-84.

Abstract: miRNAs constitute a family of small RNA species that have been demonstrated to play a central role in regulating gene expression in many...   Read More

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity (2010)

A7 SCHUMACHER Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Proc Natl Acad Sci U S A. 2010 Nov 22.

Abstract: In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins...   Read More

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