Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in... Read More
Abstract Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor... Read More
Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More
Abstract: Laminin-332 is a major component of the dermo-epidermal skin basement membrane and maintains skin integrity. The transduction of mechanical force into electrical signals... Read More
Abstract: The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function,... Read More
Abstract: A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect... Read More
Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible... Read More
Abstract: Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled... Read More
Abstract: miRNAs constitute a family of small RNA species that have been demonstrated to play a central role in regulating gene expression in many... Read More
Abstract: In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins... Read More
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