Abstract Cadherin shedding affects migration and occurs in development and cancer progression. By examining the in vivo biological function of the extracellular cadherin domain... Read More
Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play... Read More
Abstract Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). Epithelial barrier... Read More
Abstract Tissue stem cells, as well as germ line or embryonic stem cells, were shown to have reduced oxidative metabolism, which was proposed to... Read More
Abstract Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology... Read More
Abstract The specific functions of the prodomains of TGFβ superfamily members are largely unknown. Interactions are known between prodomains of TGFβ-1-3 and latent TGFβ-binding... Read More
Abstract There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves... Read More
Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J Nature 2011 Feb;470(7333):279-83 PMID: 21160473 Abstract Cell-fate transitions involve the integration of... Read More
Abstract The development of multicellular organisms, as well as maintenance of organ architecture and function, requires robust regulation of cell fates. This is... Read More
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