Expression of integrin ß1 by fibroblasts is required for tissue repair in vivo

August 3, 2010B3 ECKES KRIEG Liu S, Shi-wen X, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. J Cell Sci 123, 3674-3682, 2010

Abstract In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue... Read More

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts – role of TGFß1 levels and RhoA activity

August 3, 2010B3 ECKES KRIEG Blumbach K, Zweers MC, Brunner G, Peters AS, Schmitz M, Schulz JN, Schild A, Denton CP, Sakai T, Faessler R, Krieg T, Eckes B. J Cell Sci 123, 872-3883, 2010

Abstract Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK)... Read More

Genetic analysis of fin development in zebrafish identifies Furin and Hemicentin1 as potential novel Fraser Syndrome disease genes

August 3, 2010A9 HAMMERSCHMIDT B2 WAGENER/ PAULSSON Carney, T. J., Feitosa, N., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, R., Ingham, P.I. and Hammerschmidt, M. PLoS Genet. 6, e1000907

Abstract Using forward genetics, we have identified the genes mutated in two classes of zebrafish fin mutants. The mutants of the first class are... Read More

Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner

August 3, 2010A9 HAMMERSCHMIDT Jänicke, M., Renisch, B. and Hammerschmidt, M. Int. J. Dev. Biol. 54, 837-850.

Abstract Grainyhead/CP2 transcription factor family members are widely conserved among the animal kingdom and have been implicated in different developmental processes. Thus far, nothing... Read More

A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils

March 15, 2010B11 BAUMANN/SENGLE Otten, C., Hansen, U., Talke, A., Wagener, R., Paulsson, M., and Zaucke, F., Hum Mutat. 2010 Mar;31(3):254-63. doi: 10.1002/humu.21182

Abstract Mutations in matrilin-3 have been associated with common skeletal diseases like osteoarthritis as well as with the rare chondrodysplasias MED and SEMD. We... Read More

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation

February 12, 2010B12 SENGLETsutsui, K., Manabe, R.I., Yamada, T., Nakano, I., Oguri, Y., Keene, D.R., Sengle, G., Sakai, L.Y., and Sekiguchi, K., J Biol Chem. 2010 Feb 12;285(7):4870-82. doi: 10.1074/jbc.M109.076919. Epub 2009 Nov 23.

Abstract ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs)-like (ADAMTSL) proteins, a subgroup of the ADAMTS superfamily, share several domains with ADAMTS proteinases, including... Read More

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

January 20, 2010A11 WICKSTRÖMWickström, S.A., Lange, A., Montanez, E., and Fässler, R., EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24.

Abstract Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell... Read More

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

January 6, 2010A11 WICKSTRÖMWickström, S.A., Masoumi, K.C., Khochbin, S., Fässler, R., and Massoumi, R., EMBO J. 2010 Jan 6;29(1):131-44. doi: 10.1038/emboj.2009.317. Epub 2009 Nov 5.

Abstract CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating... Read More

The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation

December 22, 2009B11 BAUMANN/SENGLEBieniossek, C., Niederhauser, B., and Baumann, U., Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21579-84. doi: 10.1073/pnas.0910708106. Epub 2009 Dec 2.

Abstract The hexameric membrane-spanning ATP-dependent metalloprotease FtsH is universally conserved in eubacteria, mitochondria, and chloroplasts, where it fulfills key functions in quality control and... Read More

Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures

December 16, 2009B11 BAUMANN/SENGLE

Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, van Osch GJ, Zaucke F Arthritis Rheum. 2009 Dec;60(12):3676-85 PMID: 19950300 Abstract OBJECTIVE: Defects in the... Read More

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