Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer

Denzel MS, Hebbard LW, Shostak G, Shapiro L, Cardiff RD, Ranscht B Clin. Cancer Res. 2009 May;15(10):3256-64 PMID: 19447866 Abstract PURPOSE: High levels of...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERS Garinis, G.A., Uittenboogaard L.M., Stachelscheid H., van Ijcken, W. , Breit T.M., van Steeg H., Mullenders L.H.F., van der Horst G.T.J., Brüning J.C., Niessen C.M., Hoeijmakers J.H.J, and Schumacher B. Nat. Cell Biol.. 11:604-15.

Abstract The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Brüning JC,...   Read More

Clonal expansion of different mtDNA variants without selective advantage in solid tumors

Gekeler J, Zsurka G, Kunz WS, Preuss SF, Klussmann JP, Guntinas-Lichius O, Wiesner RJ Mutat. Res. 2009 Mar;662(1-2):28-32 PMID: 19114048 Abstract In search of...   Read More

Genetic and cell biological analysis of integrin outside-in signaling

A11 WICKSTRÖMLegate, K.R., Wickström, S.A., Fässler, R., Genes Dev. 2009 Feb 15;23(4):397-418. doi: 10.1101/gad.1758709.

Abstract Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their...   Read More

Crosstalk between small GTPases and polarity proteins in cell polarization

A10 IDENIden, S., Collard, J.G. (2008), Nat. Rev. Mol. Cell Biol.11, 846-59.

Abstract Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity...   Read More

A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7

B12 SENGLESengle, G., Ono, R., Lyons, K.M., Bächinger, H.P., and Sakai, L.Y., J Mol Biol. 2008 Sep 12;381(4):1025-39. doi: 10.1016/j.jmb.2008.06.074. Epub 2008 Jul 2.

Abstract Bone morphogenetic proteins (BMPs) are morphogens with long-range signaling activities. BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently...   Read More

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Wickenhauser C, Haase I, Brüning JC, Niessen CM...   Read More

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

B12 SENGLE Sengle, G., Charbonneau, N.L., Ono, R.N., Sasaki, T., Alvarez, J., Keene, D.R., Bächinger H.P., and Sakai, L.Y., J Biol Chem. 2008 May 16;283(20):13874-88. doi: 10.1074/jbc.M707820200. Epub 2008 Mar 13.

Abstract Both latent transforming growth factor-beta (TGF-beta)-binding proteins fibrillins are components of microfibril networks, and both interact with members of the TGF-beta family of...   Read More

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

B13 FABRISieling, P.A., Hill, P.J., Dobos, K.M., Brookman, K., Kuhlman, A.M., Fabri, M., Krutzik, S.R., Rea, T.H., Heaslip, D.G., Belisle, J.T., et al., J Immunol. 2008 May 1;180(9):5833-42.

Abstract CD4(+) T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an Ag...   Read More

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