publications

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

A11 WICKSTRÖMWang, H.V., Chang, L.W., Brixius, K., Wickström, S.A, Montanez, E., Thievessen, I., Schwander, M., Müller, U., Bloch, W., Mayer, U., Fässler, R., J Cell Biol. 2008 Mar 10;180(5):1037-49. doi: 10.1083/jcb.200707175

Abstract Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1...   Read More

Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry

Bazzi H, Christiano AM Curr. Opin. Cell Biol. 2007 Oct;19(5):515-20 PMID: 17951043 Abstract Desmosomal cadherins constitute the adhesive core of desmosomes. Different desmosomal cadherins...   Read More

Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M Development 2007 Oct;134(19):3461-71 PMID: 17728346 Abstract Epithelial integrity...   Read More

A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens (2007)

B11 BAUMANN/SENGLEMeier, R., Drepper, T., Svensson, V.E., Jaeger, K-E. and Baumann, U., J Biol Chem. 2007 Oct 26;282(43):31477-83. Epub 2007 Aug 28.

Abstract Lipase LipA from Serratia marcescens is a 613-amino acid enzyme belonging to family I.3 of lipolytic enzymes that has an important biotechnological application...   Read More

JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration

A10 IDENMandicourt, G., Iden, S., Ebnet, K., Aurrand-Lions, M., Imhof, B.A., J Biol Chem. 2007 Jan 19;282(3):1830-7. Epub 2006 Nov 12.

Abstract   Junctional Adhesion Molecules (JAMs) have been described as major components of tight junctions in endothelial and epithelial cells. Tight junctions are crucial...   Read More

The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis

Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM Dev. Biol. 2007 May;305(2):498-507 PMID: 17397822 Abstract Ectodermal appendage morphogenesis requires continuous epithelial-mesenchymal cross-talk...   Read More

Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression

Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM Dev. Dyn. 2007 Apr;236(4):961-70 PMID: 17330888 Abstract The mammalian epidermis is the first line...   Read More

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type

Niemann C, Owens DM, Schettina P, Watt FM Cancer Res. 2007 Apr;67(7):2916-21 PMID: 17409394 Abstract The NH(2) terminus of LEF1 is frequently mutated in...   Read More

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells (2006)

A10 IDENIden, S., Rehder, D., August, B., Suzuki, A., Noda, K., Nagafuchi, A., Wolburg-Buchholz, K., Wolburg, H., Ohno, S., Behrens, J., Vestweber, D., Ebnet, K., EMBO Rep. 2006 Dec;7(12):1239-46. Epub 2006 Oct 20.

Abstract A cell polarity complex consisting of partitioning defective 3 (PAR-3), atypical protein kinase C (aPKC) and PAR-6 has a central role in the...   Read More

Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains

A10 IDENRehder, D., Iden, S., Nasdala, I., Wegener, J., Brickwedde, M.K., Vestweber, D., Ebnet, K., Exp Cell Res. 2006 Oct 15;312(17):3389-403. Epub 2006 Jul 21

Abstract   Junctional adhesion molecule (JAM)-A is an integral membrane protein at tight junctions of epithelial cells which associates with the cell polarity protein...   Read More

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