publications

The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

Sengle G, Sakai LY Matrix Biol. 2015 Sep;47:3-12 PMID: 25957947 Abstract The fibrillins, large extracellular matrix molecules, are polymerized to form „microfibrils.“ The fibrillin...   Read More

Matrix metalloproteinase 14 is required for fibrous tissue expansion

B4 ZIGRINO MAUCHpublicationsTaylor SH, Yeung CY, Kalson NS, Lu Y, Zigrino P, Starborg T, Warwood S, Holmes DF, Canty-Laird EG, Mauch C, Kadler KE; Elife. 2015 Sep 21;4. pii: e09345. doi: 10.7554/eLife.09345.

Abstract Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is...   Read More

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

A10 IDENpublicationsSchlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5965-73. doi: 10.1167/iovs.15-17290.

Abstract PURPOSE: Conjunctival melanoma (CM) is an ocular surface tumor that can lead to fatal metastases. Patients developing, tumor-associated lymphangiogenesis have a significantly increased...   Read More

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

A11 WICKSTRÖMpublicationsMorgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA; Nat Commun. 2015 Sep 8;6:8198. doi: 10.1038/ncomms9198.

Abstract Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge...   Read More

Empty_Draft

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

publicationsKukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG; Proc Natl Acad Sci U S A. 2015 Aug 24. pii: 201512131. [Epub ahead of print]

Abstract Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the...   Read More

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

A10 IDENpublicationsTuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K; Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

Abstract Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The...   Read More

Epithelial Cell Death and Inflammation in Skin

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized...   Read More

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

A7 SCHUMACHERpublicationsEdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes....   Read More

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

A10 IDENpublicationsRefaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5691-7. doi: 10.1167/iovs.15-16829.

Abstract PURPOSE: Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior....   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

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