publications

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

A5 BRÜNING/NIESSENpublicationsWensveen FM, Jelen?i? V, Valenti? S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Poli? B; Nat Immunol. 2015 Apr;16(4):376-85. doi: 10.1038/ni.3120. Epub 2015 Mar 2.

Abstract An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the...   Read More

Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice

B3 ECKES KRIEGpublicationsPeters AS, Brunner G, Krieg T, Eckes B; Arch Dermatol Res. 2015 Mar;307(2):191-7. doi: 10.1007/s00403-014-1514-2. Epub 2014 Oct 28.

Abstract Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the...   Read More

Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions

A14 WIESNERA3 NIEMANNpublicationsKloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R; J Invest Dermatol. 2015 Mar;135(3):679-89. doi: 10.1038/jid.2014.475. Epub 2014 Nov 5.

Abstract Here, we studied how epithelial energy metabolism impacts overall skin development by selectively deleting intraepithelial mtDNA in mice by ablating a key maintenance...   Read More

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Stephan A, Fabri M Exp. Dermatol. 2015 Mar;24(3):161-6 PMID: 25421224 Abstract Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized...   Read More

Pathological implications of cadherin zonation in mouse liver

A1 NIESSENpublicationsHempel M, Schmitz A, Winkler S, Kucukoglu O, Brückner S, Niessen C, Christ B; Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.

Abstract Both acute and chronic liver diseases are associated with ample re-modeling of the liver parenchyma leading to functional impairment, which is thus obviously...   Read More

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels

publications Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG; J Cell Biol. 2015 Feb 16;208(4):429-42. doi: 10.1083/jcb.201411100.

Abstract Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. Despite the established role of mitofusins (MFN1...   Read More

A role for Rac1 activity in malignant progression of sebaceous skin tumours

A3 NIEMANNpublicationsFrances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C; Oncogene. 2015 Oct;34(43):5505-12. doi: 10.1038/onc.2014.471. Epub 2015 Feb 9.

Abstract The small GTPase Rac1 is crucial for maintaining stem cells (SCs) in mammalian epidermis, and Rac1 activation leads to SC expansion. Loss or...   Read More

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

publications Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT; EMBO Mol Med. 2015 Feb 2;7(3):275-87. doi: 10.15252/emmm.201404916.

Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of...   Read More

Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

A3 NIEMANNpublicationsPetersson M, Reuter K, Brylka H, Kraus A, Schettina P, Niemann C; Nat Commun. 2015 Jan 22;6:5874. doi: 10.1038/ncomms6874.

Abstract Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate...   Read More

Necroptosis and its role in inflammation

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis...   Read More

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