Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation

Bazzi H, Demehri S, Potter CS, Barber AG, Awgulewitsch A, Kopan R, Christiano AM

Differentiation 2009 Dec;78(5):292-300

PMID: 19683850


The hair fiber is made of specialized keratinocytes, known as trichocytes, that primarily express hair keratins, which are cemented by a multitude of keratin-associated proteins (KAPs). The hair keratins form the intermediate filament cytoskeleton of the trichocytes, which are linked to abundant cell-cell adhesion junctions, called desmosomes. Desmoglein 4 (DSG4) is the major desmosomal cadherin expressed in the hair shaft cortex where the hair keratins are highly expressed. In humans, mutations affecting either the hair keratins or DSG4 lead to beaded hair phenotypes with features of monilethrix. In this work, we postulated that the regulatory pathways governing the expression of hair shaft components, such as hair keratins and DSG4, are shared. Therefore, we studied the transcriptional regulation of DSG4 by transcription factors/pathways that are known regulators of hair keratin or KAP expression. We show that HOXC13, LEF1 and FOXN1 repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch pathway with the activation and/or maintenance of DSG4 expression in the hair follicle.

  • Upcoming Events

    1. Cologne Seminars on Ageing Series 2018 with Elaine Fuchs

      März 6 @ 4:00 pm - 5:30 pm
    2. SFB 829 Connector Meeting

      April 6 @ 3:00 pm - 5:30 pm
    3. SFB 829 Connector Meeting

      August 31 @ 3:00 pm - 5:30 pm
    4. International Symposium „Molecular Mechanisms regulating Skin Homeostasis“

      November 12 - November 14
    5. SFB 829 Connector Meeting

      Dezember 7 @ 3:00 pm - 5:30 pm
  • News

© 2017 SFB 829