University of Cologne

Collaborative Research Center (CRC 829)

The University of Cologne, DFG-funded Collaborative Research Center (CRC 829) „Molecular Mechanisms Regulating Skin Homeostasis” at the  (UoC) aims to understand how the different cellular and molecular components of the skin communicate to maintain skin homeostasis and to dissect the molecular basis by which this balance is disturbed thereby leading to skin diseases. Examples are chronic inflammatory diseases, atopic dermatitis, allergic diseases, barrier defect related diseases, and disturbed wound healing entities. The UoC-CRC 829 is employing genetic animal models, with an emphasis on transgenic mice but also including Zebrafish and Drosophila, to systematically unravel the molecular basis of these complex interactions in the skin. This will allow the identification of new therapeutic targets that can then be used to specifically interfere with defined steps leading to skin diseases. The CRC includes several core units that provide expertise in skin histology, immunohistochemistry, ultrastructural analysis as well as primary skin cell culture. In addition, they provide the consortium with a human skin disease tissue bank.

 

Carien M. Niessen
Regulation of epidermal morphogenesis and epidermal barrier function by intercellular junctions
 
Manuel Koch
Functional analysis of transmembrane collagens in skin
 
Catherin Niemann
Molecular and cellular mechanisms of hedgehog signalling in skin homeostasis
 
Manolis Pasparakis
Epithelial TNFR1 signalling in skin homeostasis and Inflammation
 
Jens C. Brüning / Carien M. Niessen
Role of the insulin/IGF-1-regulated forkhead transcription factor (FOXO)-1 in the control of skin morphogenesis, barrier function and development of diabetes associated skin complicatications
 
Thomas Benzing / Christian Reinhardt
Phosphorylation-dependent regulation of AATF controls p53-dependent apoptosis in the UV-induced DNA damage response of the skin
 
Björn Schumacher
UV-induced DNA damage in Photoaging and skin Homeostasis
 
Nils-Göran Larsson
Mitochondrial dysfunction in skin ageing
 
Matthias Hammerschmidt
Genetic analysis of skin development and wound healing in zebrafish
 
Sandra Iden
Mammalian polarity proteins in skin homeostasis and Disease
Sara A. Wickström
Regulation of epidermal stratification and homeostasis through contractility and density sensing
Roswitha Nischt
Role of basement membrane proteins in skin morphogenesis and homeostasis
 
Raimund Wagener / Mats Paulsson
Structure and function of collagen VI containing suprastructures in the dermis
 
Beate Eckes / Thomas Krieg
Role of collagen-binding integrin receptors for cellular communication and homeostasis in the skin 
 
Cornelia Mauch
Role of MMP-14 (MT1-MMP) in skin fibrosis and tissue repair
 
Sabine Eming
Functions of the inflammatory response in tissue repair
 
Ingo Haase
Regulation of skin inflammation by epidermal Keratinocytes
 
Ulrich Baumann / Frank Zaucke
Structure-function relationships of Hsp47/SerpinH1 and ist role in skin fibrosis
 
Gerhard Sengle
Extracellular fibrillin microfibrils as multifunctional scaffolds integrating growth factor signalling in the skin
 
Mario Fabri
Vitamin D regulation of the skin innate immune response
  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17
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