University of Dundee

Centre for Dermatology and Genetic Medicine (DGEM)

The University of Dundee, Welcome Trust-funded Centre for Dermatology and Genetic Medicine (DGEM) is a cross-college, multidisciplinary research initiative which has brought together highly research active, internationally renowned clinical dermatologists, biologists and geneticists with specialists in drug discovery, medicinal chemistry, biomedical physics and bioinformatics. Within DGEM there is also significant bidirectional collaboration between the National Health Service diagnostic laboratories and the University research groups, which is a prerequisite for both recruitment of patients for research, as well as the rapid translation of genetic discoveries into diagnostic practice.  Close links to clinical dermatology and genetics also enables building of genetically-defined case collections to enable future clinical trials of experimental medicines. The inception of this research grouping has already led to formation of several new translational collaborations, a number of which have recently been awarded program-level research grants from Medical Research Council, European Research Council, Cancer Research UK, The Welcome Trust and a number of skin-disease charities such as DEBRA. Most of these research programs are aimed at developing and delivering small molecule and gene-silencing therapies in skin disease.

 

Irwin McLean
Treating Genetic Disease
 
Irene Leigh
Non melanoma skin cancer from the laboratory to the clinic
 
Paul Campbell
Nucleic Acid Delivery – siRNA
 
Geoff Barton
Protein and nucleic acid sequence analysis and function prediction
 
John McGrath
Molecular basis of inherited skin disorders
 
Paul Wyatt/Andrew Woodland
Drug discovery for skin diseases
 
Charlotte Proby
Molecular mechanisms driving SCC, biomarkers and therapeutic targets
 
Andrew South
Discovering disease pathogenesis of RDEB and SCC
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