Function of mammalian cell polarity regulators in skin cancer

A10 IDENpublicationsMescher M, Iden S; Cell News 4/14.
Establishment of cell polarity and orchestrated tissue architecture
are critical to development, organ homeostasis and regeneration.
Almost every cell type in our body at least transiently
polarizes based on intrinsic cues or upon extrinsic stimuli, thereby
contributing to various organismal functions. Alterations in
adhesion, polarity and architecture of tumor cells are hallmarks
of cancer and implicated in tumor growth, invasion and metastasis.
Seminal work in Drosophila and mammalian cell culture
suggested a molecular connection between regulation of
polarity and oncogenic processes. Recent advance stems from
different mouse models that revealed a causal link between
polarity protein dysfunction and the formation and progression
of cancer. The Iden laboratory investigates the in vivo role of
mammalian polarity proteins in cell and tissue polarity, tissue
homeostasis and pathologic conditions such as cancer (Iden
and Collard 2008; Iden et al. 2012a; Ellenbroek et al. 2012).
We assess how polarity proteins including the Par3/aPKC complex
regulate growth and survival, cytoskeletal rearrangement,
fate decisions and differentiation, and how dysfunction of these
proteins affects oncogenic processes. In this focus article we
concentrate on recent insight into the role of epidermal Par3
in formation and progression of different types of skin cancer.
  • Upcoming Events

    1. Women in Science and Society with Sarah Millar

      June 19 @ 1:30 pm - 6:00 pm
    2. 9th PhD student and Postdoc Retreat

      August 22 - August 23
    3. 2nd SFB 829 Connector Meeting

      August 31 @ 3:00 pm - 5:30 pm
    4. International Symposium “Molecular Mechanisms regulating Skin Homeostasis”

      November 12 - November 14
    5. 3rd SFB 829 Connector Meeting

      December 7 @ 3:00 pm - 5:30 pm
  • News

© 2017 SFB 829

Durch die weitere Nutzung der Seite stimmst du der Verwendung von Cookies zu. Weitere Informationen

Die Cookie-Einstellungen auf dieser Website sind auf "Cookies zulassen" eingestellt, um das beste Surferlebnis zu ermöglichen. Wenn du diese Website ohne Änderung der Cookie-Einstellungen verwendest oder auf "Akzeptieren" klickst, erklärst du sich damit einverstanden.