Experimental analysis of risk factors for ulcerative dermatitis in mice

A1 NIESSENA5 BRÜNING/NIESSENNeuhaus, B., Niessen C.M., Mesaros A., Withers D.J., Krieg T. and Partridge L., Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

Abstract

Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to be fully resistant to UD. In this study, we showed that high-fat diet (HFD) feeding significantly increased incidence of UD in wild type (WT) C57BL/6 mice, as did lithium-mediated inhibition of GSK3-β, which is a key negative regulator of IRS1. In contrast to WT mice, resistance to UD was fully preserved in HFD-fed Irs1-KO mice. Our results identify IRS1 as a key determinant of UD pathogenesis and establish a direct link between diet composition, obesity-induced inflammation and chronic ulceration.

 

Pubmed

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