Impact of genomic damage and ageing on stem cell function

A7 SCHUMACHERBehrens A, van Deursen JM, Rudolph KL, Schumacher B; Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928.

Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

Pubmed

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