Home | Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells
Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells
B13 FABRIpublicationsSommer A, Fabri M; PLoS One. 2015 Jun 24;10(6):e0130395. doi: 10.1371/journal.pone.0130395. eCollection 2015.
One central mechanism, by which vitaminDregulates human immune responses, is the direct modulation of dendriticcells (DCs). However, the effect of vitaminD on several key DC functions, such as the secretion of central inflammatory cytokines, remains controversial. Moreover, whether vitaminD treatment of DCs regulates their ability to promotedifferentiation of IL-17-/IL-22-producingT cell subsets, such as Th17 and Th22 cell, is not known. Here, we report that vitaminD treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-?, IL-6, IL-1? and IL-23. Cytokines secreted by vitaminD-treated DC were significantly more potent in driving differentiation of IL-22-producingTcells, but not IL-17-producing Tcells, as compared to secreted cytokines of not-vitaminD-treated DCs. Finally, we found that the differentiation of IL-22-producingTcells mediated by supernatants of vitaminD-treated DCs was dependent on TNF-? IL-6 and IL-23. In summary, our study suggests a novel role of vitaminD in regulating DC-mediated immune responses in humans.