Home | Wound repair and regeneration: mechanisms, signaling, and translation
Wound repair and regeneration: mechanisms, signaling, and translation
B7 EMINGpublicationsEming SA, Martin P, Tomic-Canic M; Sci Transl Med. 2014 Dec 3;6(265):265sr6. doi: 10.1126/scitranslmed.3009337.
The cellular and molecular mechanisms underpinning tissue repairand its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body’s natural repairmechanisms will need to be based on a thorough understanding of the basic biology of repairandregeneration. In this review, we highlight emerging concepts in tissue regenerationandrepair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.