The CRC 829 structure of two main research areas with groups focusing on either:
Research area A (Epithelial cell function) consists of 11 projects and focuses on epithelial cells and their role in the regulation of cell-cell and cell-extracellular matrix interactions, repair and regeneration, skin immune repsonse, as well as development and maintenance of epidermal structures (including skin appendages) and barrier function in normal and pathological situations
Research area B (Non-epithelial cell function) consists of 9 projects and concentrates on non-epithelial cell types of the skin and their constitutive and induced cellular interactions that control skin homeostasis and regeneration. This area addresses the importance of these cell types and secreted extracellular matrix proteins and mediators released in disease initiation and progression.
Next to these two research areas the CRC also established four thematic clusters that
more comprehensively illustrates the functional significance of how extensive cooperation and communication within individual CRC projects, research areas and central projects furthers our discovery and understanding of key regulators of skin homeostasis.