The overall goal of the SFB 829 is to understand how molecular and cellular interactions within and between the different skin compartments are established and maintained to ensure homeostasis and to understand the key pathways by which challenges disturbing this communication cause skin disease.

To achieve this overall goal the following questions will be addressed at a molecular level:

  1. How do skin cells interact and communicate with each other (similar and different cell types)?
  2. How does contact of skin cells with the extracellular matrix modulate communication?
  3. Which are the crucial signaling pathways used for communication?
  4. How does disturbance of key pathways affect skin homeostasis and how does this result in disease?

Our overall aim is (1) to identify key communication pathways for cellular interactions in the skin, which serve to maintain tissue homeostasis, and (2) to define the role of these pathways in disease processes. In the long term this will allow to translate molecular mechanisms regulating skin homeostasis and skin disease to the design of novel therapeutic strategies.

To address these questions we have selected two sets of projects:

  • Research area A: Epithelial cell function
  • Research area B: Non-epithelial cell function

Research area A (Epithelial cell function) consists of 11 projects and focuses on epithelial cells and their role in the regulation of cell-cell and cell-extracellular matrix interactions, repair and regeneration, skin immune responses, as well as development and maintenance of epidermal structures (including skin appendages) and barrier function in normal and pathological situations.

Research are B (Non-epithelial cell function) consist of 9 projects and concentrates on non-epithelial cell types of the skin and their constitutive and induced cellular interactions that control skin homeostasis and regeneration. This area addresses the importance of these cell types and secreted extracellular matrix proteins and mediators released in disease initiation and progression.

© 2017 SFB 829

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