Tissue fibrosis: a pathomechanistically unresolved challenge and scary clinical problem

Eckes B, Eming SA

Exp. Dermatol. 2016 Aug;

PMID: 27513440


Fibrosis is defined as the replacement of healthy tissue by an excessive deposition of extracellular matrix, leading gradually to the disturbance and finally to loss of the original tissue architecture and function. Scarring and tissue fibrosis represent major unresolved medical problems resulting in increased morbidity and mortality (1). The initial tissue damage can result from multiple acute or chronic stimuli, including autoimmune reactions, infections, or mechanical injury (s1). Detailed mechanisms how tissue injury leads to tissue fibrosis and how fibrosis can be therapeutically perturbed or reversed are still poorly understood (s2; s3). A thorough investigation of the underlying molecular and cellular components is required to improve therapeutic options for the often devastating pro-fibrotic health conditions. This article is protected by copyright. All rights reserved.

  • Upcoming Events

    1. Women in Science and Society with Sarah Millar

      June 19 @ 1:30 pm - 6:00 pm
    2. 9th PhD student and Postdoc Retreat

      August 22 - August 23
    3. 2nd SFB 829 Connector Meeting

      August 31 @ 3:00 pm - 5:30 pm
    4. International Symposium “Molecular Mechanisms regulating Skin Homeostasis”

      November 12 - November 14
    5. 3rd SFB 829 Connector Meeting

      December 7 @ 3:00 pm - 5:30 pm
  • News

© 2017 SFB 829

Durch die weitere Nutzung der Seite stimmst du der Verwendung von Cookies zu. Weitere Informationen

Die Cookie-Einstellungen auf dieser Website sind auf "Cookies zulassen" eingestellt, um das beste Surferlebnis zu ermöglichen. Wenn du diese Website ohne Änderung der Cookie-Einstellungen verwendest oder auf "Akzeptieren" klickst, erklärst du sich damit einverstanden.