Yearly Archives: 2008

Crosstalk between small GTPases and polarity proteins in cell polarization

A10 IDENIden, S., Collard, J.G. (2008), Nat. Rev. Mol. Cell Biol.11, 846-59.

Abstract Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity...   Read More

A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7

B12 SENGLESengle, G., Ono, R., Lyons, K.M., Bächinger, H.P., and Sakai, L.Y., J Mol Biol. 2008 Sep 12;381(4):1025-39. doi: 10.1016/j.jmb.2008.06.074. Epub 2008 Jul 2.

Abstract Bone morphogenetic proteins (BMPs) are morphogens with long-range signaling activities. BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently...   Read More

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Wickenhauser C, Haase I, Brüning JC, Niessen CM...   Read More

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

B12 SENGLE Sengle, G., Charbonneau, N.L., Ono, R.N., Sasaki, T., Alvarez, J., Keene, D.R., Bächinger H.P., and Sakai, L.Y., J Biol Chem. 2008 May 16;283(20):13874-88. doi: 10.1074/jbc.M707820200. Epub 2008 Mar 13.

Abstract Both latent transforming growth factor-beta (TGF-beta)-binding proteins fibrillins are components of microfibril networks, and both interact with members of the TGF-beta family of...   Read More

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

B13 FABRISieling, P.A., Hill, P.J., Dobos, K.M., Brookman, K., Kuhlman, A.M., Fabri, M., Krutzik, S.R., Rea, T.H., Heaslip, D.G., Belisle, J.T., et al., J Immunol. 2008 May 1;180(9):5833-42.

Abstract CD4(+) T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an Ag...   Read More

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

A11 WICKSTRÖMWang, H.V., Chang, L.W., Brixius, K., Wickström, S.A, Montanez, E., Thievessen, I., Schwander, M., Müller, U., Bloch, W., Mayer, U., Fässler, R., J Cell Biol. 2008 Mar 10;180(5):1037-49. doi: 10.1083/jcb.200707175

Abstract Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1...   Read More

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