Yearly Archives: 2011

A7 Schumacher

UV-induced DNA damage in photoaging and skin homeostasis UV-induced DNA lesions promote photoaging and cause skin cancer development. We have established that UV-induced lesions...   Read More

A5 Brüning/Niessen

Metabolic control of skin morphogenesis, barrier function and development of diabetes associated skin complications            In the last funding periods we identified novel functions for...   Read More

SFB 829 PhD student & Postdoc Retreat 2011 with Karin Scharffetter-Kochanek (University of Ulm) and Bent Brachvogel (associated SFB 829 PI)

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

Rada-Iglesias A, Wysocka J Genome Med 2011 Jun;3(6):36 PMID: 21658297 Abstract Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent...   Read More

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

publications Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG. EMBO J. 2011 Nov 1.

Abstract Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and may, in principle, occur at many different levels. The leucine-rich pentatricopeptide...   Read More

Ciliopathies

publications Benzing T, Hildebrandt F, Katsanis N. (2011) New Engl J Med. 364 (16) :1533-43.

PubMed

Transition zone proteins and cilia dynamics

publications Benzing T, Schermer B. (2011) Nat Genetics, 43 (8) :723-4.

PubMed

The adapter protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

A4 PASPARAKISBonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva M, Bloch W, Haase I, Pasparakis M (2011) Immunity ,2011 Oct 28;35(4):572-82. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity...   Read More

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

B13 FABRIFabri, M., Stenger, S., Shin, D.M., Yuk, J.M., Liu, P.T., Realegeno, S., Lee, H.M., Krutzik, S.R., Schenk, M., Sieling, P.A., et al., Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

Abstract Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for...   Read More

Basement membrane diseases in zebrafish

A9 HAMMERSCHMIDT Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M; Methods Cell Biol. 105, 191-222

Abstract Basement membranes (BMs) are a complex, sheet-like network of specialized extracellular matrix that underlies epithelial cells and surrounds muscle cells. They provide adherence...   Read More

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