Monthly Archives: August 2011

Extracellular matrix in angiogenesis: dynamic structures with translational potential (2011)

B7 EMING Eming SA, Hubbell JA, Exp Dermatol 20(7):605-1.

Abstract: The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function,...   Read More

Sealing the gap between nuclear DNA damage and longevity (2009)

A7 SCHUMACHERB15 HOEIJMAKERS Schumacher B, Hoeijmakers JH, Garinis GA, Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7. Epub 2008 Nov 5.

Abstract: A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009)

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERS Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B, Nature Cell Biol. 2009 May;11(5):604-15.

Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development (2010)

A7 SCHUMACHERB15 HOEIJMAKERS Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W., PLoS Genet. 2010 May 6;6:e1000941.

Abstract: Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled...   Read More

Next Generation Sequencing of miRNAs – Strategies, Resources and Methods (2010)

A7 SCHUMACHER Motameny S, Wolters S, Nürnberg P, Schumacher B., Genes. 2010; 1(1):70-84.

Abstract: miRNAs constitute a family of small RNA species that have been demonstrated to play a central role in regulating gene expression in many...   Read More

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity (2010)

A7 SCHUMACHER Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Proc Natl Acad Sci U S A. 2010 Nov 22.

Abstract: In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins...   Read More

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair (2011)

publications Bouter A, Gounou C, Bérat R, Tan S, Gallois B, Granier T, d'Estaintot BL, Pöschl E, Brachvogel B, Brisson AR. Nat Commun. 2011;2:270.

Abstract: Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of plasma membrane disruptions. Before resealing, the torn membrane is submitted to...   Read More

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T,...   Read More

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

A4 PASPARAKIS Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M., J Clin Invest. 2011, 121(7):2781-93

Abstract Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role...   Read More

Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells (2010)

B2 WAGENER/ PAULSSON Grimal, S., Puech, S., Wagener, R., Ventéo, S., Carroll, P., Fichard-Carroll A. 2010. Glia. 58, 1977-87.

Abstract: Growing evidence indicates that collagens perform crucial functions during the development and organization of the nervous system. Collagen XXVIII is a recently discovered...   Read More

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