The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

September 28, 2011B3 ECKES KRIEG Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LAB, van den Berg WB, Kollias G, Eckes B, Pap T. , Arthritis Rheum 2011; accepted 16 September

Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in... Read More

TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

September 27, 2011A3 NIEMANN Petersson M, Brylka H, Kraus A, John S, Rappl G, Schettina P, and Niemann C. (2011) EMBO J. 30: 3004-3018.

Abstract Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor... Read More

CF/Lef1 mediated control of lipid metabolism regulates skin barrier function

September 27, 2011A3 NIEMANN Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser, S, Michels C, Günschmann, C, Sandhoff K, Niessen C, and Niemann C. J Invest Dermatol. Sept 2011.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons

September 12, 2011publications Chiang, LY., J. Hu, K. Poole, B.E. Oliveira, N. Duarte, A.B. Sierra, L. Bruckner-Tuderman, M. Koch, and G.R. Lewin. 2011. Nat. Neurosci 14, 993–1000

Abstract: Laminin-332 is a major component of the dermo-epidermal skin basement membrane and maintains skin integrity. The transduction of mechanical force into electrical signals... Read More

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Monthly Archives: September 2011