Yearly Archives: 2012

Z3 Bazzi & Krieg

This project has been implemented as an Integrated Research Training Group in order to serve as a structural platform for medical students, PhD students,...   Read More

B13 Fabri

Vitamin D regulation of the skin innate immune response The extra-renal vitamin D metabolism in human immune cells is central to the outcome of...   Read More

B12 Sengle

Extracellular fibrillin microfibrils as multifunctional scaffolds integrating growth factor signalling in the skin Mutations in the fibrillin genes lead to congenital multisystem disorders with...   Read More

B11 Baumann Sengle

Structure-Function Relationships of Hsp47/SerpinH1 and its Role in Skin Fibrosis Heat shock protein Hsp47 is essential for collagen biosynthesis. Elevated HS47 levels have been...   Read More

Development and homeostasis of the sebaceous gland

Niemann C, Horsley V Semin. Cell Dev. Biol. 2012 Oct;23(8):928-36 PMID: 22960253 Abstract The important role of epidermal appendages especially the sebaceous gland has...   Read More

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J Cell Stem Cell 2012 Nov;11(5):633-48 PMID: 22981823 Abstract Neural crest cells (NCC)...   Read More

SFB 829 PhD student & Postdoc Retreat 2012 with Arnoud Sonnenberg (Netherlands Cancer Institute) and Beate Eckes (SFB 829 PI)

Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization

B4 ZIGRINO MAUCHZigrino, P., Ayachi, O., Schild, A., Zamek, J., Kaltenberg, J., Nischt, R., Koch, M., and Mauch, C., Eur J Cell Biol. 2012 Oct;91(10):748-56. doi: 10.1016/j.ejcb.2012.05.003. Epub 2012 Jun 18.

Abstract Synthesis and activation of matrix metalloproteinases during wound healing are important for remodeling the extracellular matrix and modulating various cellular functions. The membrane-type...   Read More

Experimental analysis of risk factors for ulcerative dermatitis in mice

A1 NIESSENA5 BRÜNING/NIESSENNeuhaus, B., Niessen C.M., Mesaros A., Withers D.J., Krieg T. and Partridge L., Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

Abstract Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to...   Read More

Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures

B11 BAUMANN/SENGLEB2 WAGENER/ PAULSSONBechtel, M., Keller, M., Bloch, W., Sasaki, T., Boukamp, P., Zaucke, F., Paulsson, M., and Nischt, R., FASEB J. 2012 Sep;26(9):3637-48. doi: 10.1096/fj.11-194597. Epub 2012 May 23.

Abstract Nidogen-1 and nidogen-2 are homologous proteins found in all basement membranes (BMs). They show comparable binding activities in vitro and partially redundant functions...   Read More

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